ZnS-nanocrystals/polypyrrole nanocomposite film based immunosensor

Sujeet K. Mishra, Renu Pasricha, Ashok M. Biradar, Rajesh

Research output: Contribution to journalArticle

Abstract

We report an electrochemically synthesized ZnS nanocrystals modified polypyrrole (PPy) nanocomposite film based immunosensor for the detection of C-reactive protein (CRP). The ZnS-PPy composite film was characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM) and electrochemical techniques. The modified film showed good biocompatibility with efficient binding to protein antibody (αCRP-Ab) molecules through ZnS nanocrystals, exhibited an attractive platform for immunosensor fabrication. The electrical and sensing properties of the polymer composite film of different thickness towards protein antigen (αCRP-Ag) were delineated. The immunosensor exhibited an impedance response to αCRP-Ag concentration in a linear range from 10 ng to 10 g mL -1.

Original languageEnglish (US)
Article number053701
JournalApplied Physics Letters
Volume100
Issue number5
DOIs
StatePublished - Jan 30 2012

Fingerprint

polypyrroles
nanocomposites
nanocrystals
proteins
composite materials
biocompatibility
antigens
antibodies
platforms
electrical properties
atomic force microscopy
impedance
transmission electron microscopy
fabrication
polymers
molecules

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

ZnS-nanocrystals/polypyrrole nanocomposite film based immunosensor. / Mishra, Sujeet K.; Pasricha, Renu; Biradar, Ashok M.; Rajesh.

In: Applied Physics Letters, Vol. 100, No. 5, 053701, 30.01.2012.

Research output: Contribution to journalArticle

Mishra, Sujeet K. ; Pasricha, Renu ; Biradar, Ashok M. ; Rajesh. / ZnS-nanocrystals/polypyrrole nanocomposite film based immunosensor. In: Applied Physics Letters. 2012 ; Vol. 100, No. 5.
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