Abstract
3,3′-Substituted BINOL's have been identified as suitable chiral ligands for the zirconium-catalyzed aldol-Tishchenko reaction of aromatic ketone aldols with aliphatic aldehydes. 1,3-anti-Diol monoesters were obtained in excellent yields, complete anti-diastereocontrol, and enantioselectivities of up to 60% ee.
Original language | English (US) |
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Pages (from-to) | 2738-2742 |
Number of pages | 5 |
Journal | Tetrahedron Asymmetry |
Volume | 17 |
Issue number | 19 |
DOIs | |
State | Published - Oct 27 2006 |
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ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
Cite this
Zirconium-BINOLate-catalyzed, enantioselective aldol-Tishchenko reactions of aromatic ketone aldols. / Schneider, Christoph; Hansch, Markus; Pankajakshan, Sreekumar.
In: Tetrahedron Asymmetry, Vol. 17, No. 19, 27.10.2006, p. 2738-2742.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Zirconium-BINOLate-catalyzed, enantioselective aldol-Tishchenko reactions of aromatic ketone aldols
AU - Schneider, Christoph
AU - Hansch, Markus
AU - Pankajakshan, Sreekumar
PY - 2006/10/27
Y1 - 2006/10/27
N2 - 3,3′-Substituted BINOL's have been identified as suitable chiral ligands for the zirconium-catalyzed aldol-Tishchenko reaction of aromatic ketone aldols with aliphatic aldehydes. 1,3-anti-Diol monoesters were obtained in excellent yields, complete anti-diastereocontrol, and enantioselectivities of up to 60% ee.
AB - 3,3′-Substituted BINOL's have been identified as suitable chiral ligands for the zirconium-catalyzed aldol-Tishchenko reaction of aromatic ketone aldols with aliphatic aldehydes. 1,3-anti-Diol monoesters were obtained in excellent yields, complete anti-diastereocontrol, and enantioselectivities of up to 60% ee.
UR - http://www.scopus.com/inward/record.url?scp=33751163266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751163266&partnerID=8YFLogxK
U2 - 10.1016/j.tetasy.2006.10.019
DO - 10.1016/j.tetasy.2006.10.019
M3 - Article
AN - SCOPUS:33751163266
VL - 17
SP - 2738
EP - 2742
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
SN - 0957-4166
IS - 19
ER -