Xenopus FK 506-binding protein, a novel immunophilin expressed during early development

Rebecca Spokony, Jean-Pierre Saint-Jeannet

Research output: Contribution to journalArticle

Abstract

FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalMechanisms of Development
Volume94
Issue number1-2
DOIs
StatePublished - Jun 1 2000

Fingerprint

Xenopus Proteins
Immunophilins
Tacrolimus Binding Proteins
Notochord
Xenopus
Branchial Region
Gastrula
Somites
Tacrolimus
Mesoderm
Sirolimus
Immunosuppressive Agents
Sequence Homology
Epidermis
Embryonic Development
Testis
Organism Cloning
Immune System
Proteins
Messenger RNA

Keywords

  • Branchial arches
  • Epidermis
  • FK 506-binding protein
  • Immunophilin
  • Mesoderm
  • Notochord
  • Somite
  • Xenopus laevis

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Xenopus FK 506-binding protein, a novel immunophilin expressed during early development. / Spokony, Rebecca; Saint-Jeannet, Jean-Pierre.

In: Mechanisms of Development, Vol. 94, No. 1-2, 01.06.2000, p. 205-208.

Research output: Contribution to journalArticle

@article{72ef4bbf42ba46a5946c832e56f8f949,
title = "Xenopus FK 506-binding protein, a novel immunophilin expressed during early development",
abstract = "FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.",
keywords = "Branchial arches, Epidermis, FK 506-binding protein, Immunophilin, Mesoderm, Notochord, Somite, Xenopus laevis",
author = "Rebecca Spokony and Jean-Pierre Saint-Jeannet",
year = "2000",
month = "6",
day = "1",
doi = "10.1016/S0925-4773(00)00315-4",
language = "English (US)",
volume = "94",
pages = "205--208",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Xenopus FK 506-binding protein, a novel immunophilin expressed during early development

AU - Spokony, Rebecca

AU - Saint-Jeannet, Jean-Pierre

PY - 2000/6/1

Y1 - 2000/6/1

N2 - FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.

AB - FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.

KW - Branchial arches

KW - Epidermis

KW - FK 506-binding protein

KW - Immunophilin

KW - Mesoderm

KW - Notochord

KW - Somite

KW - Xenopus laevis

UR - http://www.scopus.com/inward/record.url?scp=0034212392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034212392&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(00)00315-4

DO - 10.1016/S0925-4773(00)00315-4

M3 - Article

C2 - 10842073

AN - SCOPUS:0034212392

VL - 94

SP - 205

EP - 208

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 1-2

ER -