World Workshop on Oral Medicine VI

A systematic review of the treatment of mucous membrane pemphigoid

J. Taylor, R. McMillan, M. Shephard, J. Setterfield, R. Ahmed, M. Carrozzo, S. Grando, M. Mignogna, M. Kuten-Shorrer, T. Musbah, A. Elia, R. McGowan, A. R. Kerr, M. S. Greenberg, T. Hodgson, David Sirois

Research output: Contribution to journalArticle

Abstract

Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

Original languageEnglish (US)
Pages (from-to)161-171e20
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume120
Issue number2
DOIs
StatePublished - 2015

Fingerprint

Oral Medicine
Bullous Pemphigoid
Observational Studies
Mucous Membrane
Randomized Controlled Trials
Education
Cyclophosphamide
Adrenal Cortex Hormones
Pentoxifylline
Intravenous Immunoglobulins
Controlled Clinical Trials
Fluorescent Antibody Technique
Therapeutics
Safety
Research

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Dentistry (miscellaneous)

Cite this

World Workshop on Oral Medicine VI : A systematic review of the treatment of mucous membrane pemphigoid. / Taylor, J.; McMillan, R.; Shephard, M.; Setterfield, J.; Ahmed, R.; Carrozzo, M.; Grando, S.; Mignogna, M.; Kuten-Shorrer, M.; Musbah, T.; Elia, A.; McGowan, R.; Kerr, A. R.; Greenberg, M. S.; Hodgson, T.; Sirois, David.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 120, No. 2, 2015, p. 161-171e20.

Research output: Contribution to journalArticle

Taylor, J, McMillan, R, Shephard, M, Setterfield, J, Ahmed, R, Carrozzo, M, Grando, S, Mignogna, M, Kuten-Shorrer, M, Musbah, T, Elia, A, McGowan, R, Kerr, AR, Greenberg, MS, Hodgson, T & Sirois, D 2015, 'World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 120, no. 2, pp. 161-171e20. https://doi.org/10.1016/j.oooo.2015.01.024
Taylor, J. ; McMillan, R. ; Shephard, M. ; Setterfield, J. ; Ahmed, R. ; Carrozzo, M. ; Grando, S. ; Mignogna, M. ; Kuten-Shorrer, M. ; Musbah, T. ; Elia, A. ; McGowan, R. ; Kerr, A. R. ; Greenberg, M. S. ; Hodgson, T. ; Sirois, David. / World Workshop on Oral Medicine VI : A systematic review of the treatment of mucous membrane pemphigoid. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2015 ; Vol. 120, No. 2. pp. 161-171e20.
@article{b722484d16c642288f8908dda469fb98,
title = "World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid",
abstract = "Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.",
author = "J. Taylor and R. McMillan and M. Shephard and J. Setterfield and R. Ahmed and M. Carrozzo and S. Grando and M. Mignogna and M. Kuten-Shorrer and T. Musbah and A. Elia and R. McGowan and Kerr, {A. R.} and Greenberg, {M. S.} and T. Hodgson and David Sirois",
year = "2015",
doi = "10.1016/j.oooo.2015.01.024",
language = "English (US)",
volume = "120",
pages = "161--171e20",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - World Workshop on Oral Medicine VI

T2 - A systematic review of the treatment of mucous membrane pemphigoid

AU - Taylor, J.

AU - McMillan, R.

AU - Shephard, M.

AU - Setterfield, J.

AU - Ahmed, R.

AU - Carrozzo, M.

AU - Grando, S.

AU - Mignogna, M.

AU - Kuten-Shorrer, M.

AU - Musbah, T.

AU - Elia, A.

AU - McGowan, R.

AU - Kerr, A. R.

AU - Greenberg, M. S.

AU - Hodgson, T.

AU - Sirois, David

PY - 2015

Y1 - 2015

N2 - Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

AB - Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

UR - http://www.scopus.com/inward/record.url?scp=84944160034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944160034&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2015.01.024

DO - 10.1016/j.oooo.2015.01.024

M3 - Article

VL - 120

SP - 161-171e20

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 2

ER -