Wnt-frizzled signaling in neural crest formation

Jinling Wu, Jean-Pierre Saint-Jeannet, Peter S. Klein

Research output: Contribution to journalArticle

Abstract

The neural crest is a unique embryonic structure composed of a migratory population of multipotent cells. It is induced at the border of neural and epidermal tissues and contributes to a numerous cell types in the developing vertebrate embryo. The induction of neural crest has been proposed to be a multi-step process, involving an intermediate level of signaling by bone morphogenetic proteins (BMPs) and additional signals from adjacent tissues. Although these signals have not been identified with certainty, evidence from work in Xenopus and mouse, and more recently in chick and zebrafish, supports a role for the Wnt signaling pathway in the early steps of neural crest development.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalTrends in Neurosciences
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Neural Crest
Embryonic Structures
Bone Morphogenetic Proteins
Wnt Signaling Pathway
Zebrafish
Xenopus
Vertebrates
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wnt-frizzled signaling in neural crest formation. / Wu, Jinling; Saint-Jeannet, Jean-Pierre; Klein, Peter S.

In: Trends in Neurosciences, Vol. 26, No. 1, 01.01.2003, p. 40-45.

Research output: Contribution to journalArticle

Wu, Jinling ; Saint-Jeannet, Jean-Pierre ; Klein, Peter S. / Wnt-frizzled signaling in neural crest formation. In: Trends in Neurosciences. 2003 ; Vol. 26, No. 1. pp. 40-45.
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