Will HIV vaccination reshape HIV risk behavior networks? A social network analysis of drug users' anticipated risk compensation

April M. Young, Daniel S. Halgin, Ralph DiClemente, Claire E. Sterk, Jennifer R. Havens

Research output: Contribution to journalArticle

Abstract

Background: An HIV vaccine could substantially impact the epidemic. However, risk compensation (RC), or post-vaccination increase in risk behavior, could present a major challenge. The methodology used in previous studies of risk compensation has been almost exclusively individual-level in focus, and has not explored how increased risk behavior could affect the connectivity of risk networks. This study examined the impact of anticipated HIV vaccine-related RC on the structure of high-risk drug users' sexual and injection risk network. Methods: A sample of 433 rural drug users in the US provided data on their risk relationships (i.e., those involving recent unprotected sex and/or injection equipment sharing). Dyad-specific data were collected on likelihood of increasing/ initiating risk behavior if they, their partner, or they and their partner received an HIV vaccine. Using these data and social network analysis, a "post-vaccination network" was constructed and compared to the current network on measures relevant to HIV transmission, including network size, cohesiveness (e.g., diameter, component structure, density), and centrality. Results: Participants reported 488 risk relationships. Few reported an intention to decrease condom use or increase equipment sharing (4% and 1%, respectively). RC intent was reported in 30 existing risk relationships and vaccination was anticipated to elicit the formation of five new relationships. RC resulted in a 5% increase in risk network size (n = 142 to n = 149) and a significant increase in network density. The initiation of risk relationships resulted in the connection of otherwise disconnected network components, with the largest doubling in size from five to ten. Conclusions: This study demonstrates a new methodological approach to studying RC and reveals that behavior change following HIV vaccination could potentially impact risk network connectivity. These data will be valuable in parameterizing future network models that can determine if network-level change precipitated by RC would appreciably impact the vaccine's population-level effectiveness.

Original languageEnglish (US)
Article numbere101047
JournalPLoS One
Volume9
Issue number7
DOIs
StatePublished - Jul 3 2014

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risk behavior
social networks
Electric network analysis
Risk-Taking
Drug Users
Social Support
Vaccination
vaccination
HIV
drugs
Pharmaceutical Preparations
AIDS Vaccines
vaccines
Compensation and Redress
injection
Unsafe Sex
Equipment and Supplies
Injections
Condoms
Network components

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Will HIV vaccination reshape HIV risk behavior networks? A social network analysis of drug users' anticipated risk compensation. / Young, April M.; Halgin, Daniel S.; DiClemente, Ralph; Sterk, Claire E.; Havens, Jennifer R.

In: PLoS One, Vol. 9, No. 7, e101047, 03.07.2014.

Research output: Contribution to journalArticle

Young, April M. ; Halgin, Daniel S. ; DiClemente, Ralph ; Sterk, Claire E. ; Havens, Jennifer R. / Will HIV vaccination reshape HIV risk behavior networks? A social network analysis of drug users' anticipated risk compensation. In: PLoS One. 2014 ; Vol. 9, No. 7.
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