Widespread genetic incompatibility in C. elegans maintained by balancing selection

Hannah S. Seidel, Matthew Rockman, Leonid Kruglyak

Research output: Contribution to journalArticle

Abstract

Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalScience
Volume319
Issue number5863
DOIs
StatePublished - Feb 1 2008

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Haplotypes
Genetic Selection
Alleles
Gene Flow
Linkage Disequilibrium
Caenorhabditis elegans
Population Genetics
Population
Spermatozoa
Embryonic Structures
Genome
Genes
Paternal Inheritance

ASJC Scopus subject areas

  • General

Cite this

Widespread genetic incompatibility in C. elegans maintained by balancing selection. / Seidel, Hannah S.; Rockman, Matthew; Kruglyak, Leonid.

In: Science, Vol. 319, No. 5863, 01.02.2008, p. 589-594.

Research output: Contribution to journalArticle

Seidel, Hannah S. ; Rockman, Matthew ; Kruglyak, Leonid. / Widespread genetic incompatibility in C. elegans maintained by balancing selection. In: Science. 2008 ; Vol. 319, No. 5863. pp. 589-594.
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