Whole-eye transplantation: A look into the past and vision for the future

D. Bourne, Y. Li, C. Komatsu, M. R. Miller, E. H. Davidson, L. He, I. A. Rosner, H. Tang, W. Chen, M. G. Solari, J. S. Schuman, K. M. Washington

    Research output: Contribution to journalArticle

    Abstract

    Blindness afflicts ∼39 million people worldwide. Retinal ganglion cells are unable to regenerate, making this condition irreversible in many cases. Whole-eye transplantation (WET) provides the opportunity to replace diseased retinal ganglion cells, as well as the entire optical system and surrounding facial tissue, if necessary. Recent success in face transplantation demonstrates that this may be a promising treatment for what has been to this time an incurable condition. An animal model for WET must be established to further enhance our knowledge of nerve regeneration, immunosuppression, and technical aspects of surgery. A systematic review of the literature was performed to evaluate studies describing animal models for WET. Only articles in which the eye was completely enucleated and reimplanted were included. Study methods and results were compared. In the majority of published literature, WET can result in recovery of vision in cold-blooded vertebrates. There are a few instances in which mammalian WET models demonstrate survival of the transplanted tissue following neurovascular anastomosis and the ability to maintain brief electroretinogram activity in the new host. In this study we review in cold-blooded vertebrates and mammalian animal models for WET and discuss prospects for future research for translation to human eye transplantation.

    Original languageEnglish (US)
    Pages (from-to)179-184
    Number of pages6
    JournalEye (Basingstoke)
    Volume31
    Issue number2
    DOIs
    StatePublished - Feb 1 2017

      Fingerprint

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems

    Cite this

    Bourne, D., Li, Y., Komatsu, C., Miller, M. R., Davidson, E. H., He, L., Rosner, I. A., Tang, H., Chen, W., Solari, M. G., Schuman, J. S., & Washington, K. M. (2017). Whole-eye transplantation: A look into the past and vision for the future. Eye (Basingstoke), 31(2), 179-184. https://doi.org/10.1038/eye.2016.272