Whispering-gallery-mode biosensing

Label-free detection down to single molecules

Frank Vollmer, Stephen Arnold

Research output: Contribution to journalArticle

Abstract

Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalNature Methods
Volume5
Issue number7
DOIs
StatePublished - Jul 2008

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Whispering gallery modes
Surface Plasmon Resonance
Biosensing Techniques
Labels
Molecules
Microcavities
Surface plasmon resonance
Biosensors
Detectors
Sensors

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Molecular Biology

Cite this

Whispering-gallery-mode biosensing : Label-free detection down to single molecules. / Vollmer, Frank; Arnold, Stephen.

In: Nature Methods, Vol. 5, No. 7, 07.2008, p. 591-596.

Research output: Contribution to journalArticle

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