Whispering-gallery-mode biosensing: Label-free detection down to single molecules

Frank Vollmer, Stephen Arnold

Research output: Contribution to journalArticle

Abstract

Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalNature methods
Volume5
Issue number7
DOIs
StatePublished - Jul 1 2008

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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