What is memory? The present state of the engram

Mu ming Poo, Michele Pignatelli, Tomás J. Ryan, Susumu Tonegawa, Tobias Bonhoeffer, Kelsey C. Martin, Andrii Rudenko, Li Huei Tsai, Richard W. Tsien, Gordon Fishell, Caitlin Mullins, J. Tiago Gonçalves, Matthew Shtrahman, Stephen T. Johnston, Fred H. Gage, Yang Dan, John Long, György Buzsáki, Charles Stevens

Research output: Contribution to journalArticle

Abstract

The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous "excitations", whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.

Original languageEnglish (US)
Article number40
JournalBMC Biology
Volume14
Issue number1
DOIs
StatePublished - May 19 2016

Fingerprint

zoologists
Data storage equipment
Biological Sciences
outreach
brain
Brain

ASJC Scopus subject areas

  • Biotechnology
  • Structural Biology
  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Plant Science
  • Developmental Biology
  • Cell Biology

Cite this

Poo, M. M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., ... Stevens, C. (2016). What is memory? The present state of the engram. BMC Biology, 14(1), [40]. https://doi.org/10.1186/s12915-016-0261-6

What is memory? The present state of the engram. / Poo, Mu ming; Pignatelli, Michele; Ryan, Tomás J.; Tonegawa, Susumu; Bonhoeffer, Tobias; Martin, Kelsey C.; Rudenko, Andrii; Tsai, Li Huei; Tsien, Richard W.; Fishell, Gordon; Mullins, Caitlin; Gonçalves, J. Tiago; Shtrahman, Matthew; Johnston, Stephen T.; Gage, Fred H.; Dan, Yang; Long, John; Buzsáki, György; Stevens, Charles.

In: BMC Biology, Vol. 14, No. 1, 40, 19.05.2016.

Research output: Contribution to journalArticle

Poo, MM, Pignatelli, M, Ryan, TJ, Tonegawa, S, Bonhoeffer, T, Martin, KC, Rudenko, A, Tsai, LH, Tsien, RW, Fishell, G, Mullins, C, Gonçalves, JT, Shtrahman, M, Johnston, ST, Gage, FH, Dan, Y, Long, J, Buzsáki, G & Stevens, C 2016, 'What is memory? The present state of the engram', BMC Biology, vol. 14, no. 1, 40. https://doi.org/10.1186/s12915-016-0261-6
Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC et al. What is memory? The present state of the engram. BMC Biology. 2016 May 19;14(1). 40. https://doi.org/10.1186/s12915-016-0261-6
Poo, Mu ming ; Pignatelli, Michele ; Ryan, Tomás J. ; Tonegawa, Susumu ; Bonhoeffer, Tobias ; Martin, Kelsey C. ; Rudenko, Andrii ; Tsai, Li Huei ; Tsien, Richard W. ; Fishell, Gordon ; Mullins, Caitlin ; Gonçalves, J. Tiago ; Shtrahman, Matthew ; Johnston, Stephen T. ; Gage, Fred H. ; Dan, Yang ; Long, John ; Buzsáki, György ; Stevens, Charles. / What is memory? The present state of the engram. In: BMC Biology. 2016 ; Vol. 14, No. 1.
@article{3b2c9ea9688d436da58664bf9e96e38d,
title = "What is memory? The present state of the engram",
abstract = "The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous {"}excitations{"}, whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.",
author = "Poo, {Mu ming} and Michele Pignatelli and Ryan, {Tom{\'a}s J.} and Susumu Tonegawa and Tobias Bonhoeffer and Martin, {Kelsey C.} and Andrii Rudenko and Tsai, {Li Huei} and Tsien, {Richard W.} and Gordon Fishell and Caitlin Mullins and Gon{\cc}alves, {J. Tiago} and Matthew Shtrahman and Johnston, {Stephen T.} and Gage, {Fred H.} and Yang Dan and John Long and Gy{\"o}rgy Buzs{\'a}ki and Charles Stevens",
year = "2016",
month = "5",
day = "19",
doi = "10.1186/s12915-016-0261-6",
language = "English (US)",
volume = "14",
journal = "BMC Biology",
issn = "1741-7007",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - What is memory? The present state of the engram

AU - Poo, Mu ming

AU - Pignatelli, Michele

AU - Ryan, Tomás J.

AU - Tonegawa, Susumu

AU - Bonhoeffer, Tobias

AU - Martin, Kelsey C.

AU - Rudenko, Andrii

AU - Tsai, Li Huei

AU - Tsien, Richard W.

AU - Fishell, Gordon

AU - Mullins, Caitlin

AU - Gonçalves, J. Tiago

AU - Shtrahman, Matthew

AU - Johnston, Stephen T.

AU - Gage, Fred H.

AU - Dan, Yang

AU - Long, John

AU - Buzsáki, György

AU - Stevens, Charles

PY - 2016/5/19

Y1 - 2016/5/19

N2 - The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous "excitations", whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.

AB - The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous "excitations", whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.

UR - http://www.scopus.com/inward/record.url?scp=84969506295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969506295&partnerID=8YFLogxK

U2 - 10.1186/s12915-016-0261-6

DO - 10.1186/s12915-016-0261-6

M3 - Article

VL - 14

JO - BMC Biology

JF - BMC Biology

SN - 1741-7007

IS - 1

M1 - 40

ER -