Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers

Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Jed T. Elison, Jason J. Wolff, Lyndsey Cole, Wei Gao, Juhi Pandey, Mark D. Shen, Meghan R. Swanson, Robert W. Emerson, Cheryl L. Klohr, Chloe M. Adams, Annette M. Estes, Lonnie Zwaigenbaum, Kelly N. Botteron, Robert C. McKinstry, John N. Constantino, Alan C. Evans, Heather C. HazlettStephen R. Dager, Sarah J. Paterson, Robert T. Schultz, Martin A. Styner, Guido Gerig, Bradley L. Schlaggar, Joseph Piven, John R. Pruett

    Research output: Contribution to journalArticle

    Abstract

    Infant gross motor development is vital to adaptive function and predictive of both cognitive outcomes and neurodevelopmental disorders. However, little is known about neural systems underlying the emergence of walking and general gross motor abilities. Using resting state fcMRI, we identified functional brain networks associated with walking and gross motor scores in a mixed cross-sectional and longitudinal cohort of infants at high and low risk for autism spectrum disorder, who represent a dimensionally distributed range of motor function. At age 12 months, functional connectivity of motor and default mode networks was correlated with walking, whereas dorsal attention and posterior cingulo-opercular networks were implicated at age 24 months. Analyses of general gross motor function also revealed involvement of motor and default mode networks at 12 and 24 months, with dorsal attention, cingulo-opercular, frontoparietal, and subcortical networks additionally implicated at 24 months. These findings suggest that changes in network-level brain-behavior relationships underlie the emergence and consolidation of walking and gross motor abilities in the toddler period. This initial description of network substrates of early gross motor development may inform hypotheses regarding neural systems contributing to typical and atypical motor outcomes, as well as neurodevelopmental disorders associated with motor dysfunction.

    Original languageEnglish (US)
    Pages (from-to)750-763
    Number of pages14
    JournalCerebral Cortex
    Volume28
    Issue number2
    DOIs
    StatePublished - Feb 1 2018

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    Walking
    Aptitude
    Brain
    Neurodevelopmental Disorders

    Keywords

    • functional connectivity
    • gross motor
    • infant
    • network
    • walking

    ASJC Scopus subject areas

    • Cognitive Neuroscience
    • Cellular and Molecular Neuroscience

    Cite this

    Marrus, N., Eggebrecht, A. T., Todorov, A., Elison, J. T., Wolff, J. J., Cole, L., ... Pruett, J. R. (2018). Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers. Cerebral Cortex, 28(2), 750-763. https://doi.org/10.1093/cercor/bhx313

    Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers. / Marrus, Natasha; Eggebrecht, Adam T.; Todorov, Alexandre; Elison, Jed T.; Wolff, Jason J.; Cole, Lyndsey; Gao, Wei; Pandey, Juhi; Shen, Mark D.; Swanson, Meghan R.; Emerson, Robert W.; Klohr, Cheryl L.; Adams, Chloe M.; Estes, Annette M.; Zwaigenbaum, Lonnie; Botteron, Kelly N.; McKinstry, Robert C.; Constantino, John N.; Evans, Alan C.; Hazlett, Heather C.; Dager, Stephen R.; Paterson, Sarah J.; Schultz, Robert T.; Styner, Martin A.; Gerig, Guido; Schlaggar, Bradley L.; Piven, Joseph; Pruett, John R.

    In: Cerebral Cortex, Vol. 28, No. 2, 01.02.2018, p. 750-763.

    Research output: Contribution to journalArticle

    Marrus, N, Eggebrecht, AT, Todorov, A, Elison, JT, Wolff, JJ, Cole, L, Gao, W, Pandey, J, Shen, MD, Swanson, MR, Emerson, RW, Klohr, CL, Adams, CM, Estes, AM, Zwaigenbaum, L, Botteron, KN, McKinstry, RC, Constantino, JN, Evans, AC, Hazlett, HC, Dager, SR, Paterson, SJ, Schultz, RT, Styner, MA, Gerig, G, Schlaggar, BL, Piven, J & Pruett, JR 2018, 'Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers', Cerebral Cortex, vol. 28, no. 2, pp. 750-763. https://doi.org/10.1093/cercor/bhx313
    Marrus N, Eggebrecht AT, Todorov A, Elison JT, Wolff JJ, Cole L et al. Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers. Cerebral Cortex. 2018 Feb 1;28(2):750-763. https://doi.org/10.1093/cercor/bhx313
    Marrus, Natasha ; Eggebrecht, Adam T. ; Todorov, Alexandre ; Elison, Jed T. ; Wolff, Jason J. ; Cole, Lyndsey ; Gao, Wei ; Pandey, Juhi ; Shen, Mark D. ; Swanson, Meghan R. ; Emerson, Robert W. ; Klohr, Cheryl L. ; Adams, Chloe M. ; Estes, Annette M. ; Zwaigenbaum, Lonnie ; Botteron, Kelly N. ; McKinstry, Robert C. ; Constantino, John N. ; Evans, Alan C. ; Hazlett, Heather C. ; Dager, Stephen R. ; Paterson, Sarah J. ; Schultz, Robert T. ; Styner, Martin A. ; Gerig, Guido ; Schlaggar, Bradley L. ; Piven, Joseph ; Pruett, John R. / Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers. In: Cerebral Cortex. 2018 ; Vol. 28, No. 2. pp. 750-763.
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