Vitamin D status and early age-related macular degeneration in postmenopausal women

Amy E. Millen, Rick Voland, Sherie A. Sondel, Niyati Parekh, Ronald L. Horst, Robert B. Wallace, Gregory S. Hageman, Rick Chappell, Barbara A. Blodi, Michael L. Klein, Karen M. Gehrs, Gloria E. Sarto, Julie A. Mares

Research output: Contribution to journalArticle

Abstract

Objective: The relationship between serum 25-hydroxyvitamin D (25[OH]D) concentrations (nmol/L) and the prevalence of early age-related macular degeneration (AMD) was investigated in participants of the Carotenoids in Age-Related Eye Disease Study. Methods: Stereoscopic fundus photographs, taken from 2001 to 2004, assessed AMD status. Baseline (1994-1998) serum samples were available for 25(OH)D assays in 1313 women with complete ocular and risk factor data. Odds ratios (ORs) and 95% confidence intervals (CIs) for early AMD (n=241) of 1287 without advanced disease were estimated with logistic regression and adjusted for age, smoking, iris pigmentation, family history of AMD, cardiovascular disease, diabetes, and hormone therapy use. Results: In multivariate models, no significant relationship was observed between earlyAMDand 25(OH)D (OR for quintile 5 vs 1, 0.79; 95% CI, 0.50-1.24; P for trend=.47). A significant age interaction (P=.002) suggested selective mortality bias in women aged 75 years and older: serum 25(OH)D was associated with decreased odds of early AMD in women younger than 75 years (n=968) and increased odds in women aged 75 years or older (n=319) (OR for quintile 5 vs 1, 0.52; 95% CI, 0.29-0.91; P for trend=.02 and OR, 1.76; 95% CI, 0.77-4.13; P for trend=.05, respectively). Further adjustment for body mass index and recreational physical activity, predictors of 25(OH)D, attenuated the observed association in women younger than 75 years. Additionally, among women younger than 75 years, intake of vitamin D from foods and supplements was related to decreased odds of early AMD in multivariate models; no relationship was observed with self-reported time spent in direct sunlight. Conclusions: High serum 25(OH)D concentrations may protect against early AMD in women younger than 75 years.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalArchives of Ophthalmology
Volume129
Issue number4
DOIs
StatePublished - Apr 2011

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Macular Degeneration
Vitamin D
Odds Ratio
Confidence Intervals
Serum
Eye Diseases
Sunlight
Pigmentation
Iris
Carotenoids
Dietary Supplements
Body Mass Index
Cardiovascular Diseases
Logistic Models
Smoking
Hormones
Exercise
Mortality

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Millen, A. E., Voland, R., Sondel, S. A., Parekh, N., Horst, R. L., Wallace, R. B., ... Mares, J. A. (2011). Vitamin D status and early age-related macular degeneration in postmenopausal women. Archives of Ophthalmology, 129(4), 481-489. https://doi.org/10.1001/archophthalmol.2011.48

Vitamin D status and early age-related macular degeneration in postmenopausal women. / Millen, Amy E.; Voland, Rick; Sondel, Sherie A.; Parekh, Niyati; Horst, Ronald L.; Wallace, Robert B.; Hageman, Gregory S.; Chappell, Rick; Blodi, Barbara A.; Klein, Michael L.; Gehrs, Karen M.; Sarto, Gloria E.; Mares, Julie A.

In: Archives of Ophthalmology, Vol. 129, No. 4, 04.2011, p. 481-489.

Research output: Contribution to journalArticle

Millen, AE, Voland, R, Sondel, SA, Parekh, N, Horst, RL, Wallace, RB, Hageman, GS, Chappell, R, Blodi, BA, Klein, ML, Gehrs, KM, Sarto, GE & Mares, JA 2011, 'Vitamin D status and early age-related macular degeneration in postmenopausal women', Archives of Ophthalmology, vol. 129, no. 4, pp. 481-489. https://doi.org/10.1001/archophthalmol.2011.48
Millen, Amy E. ; Voland, Rick ; Sondel, Sherie A. ; Parekh, Niyati ; Horst, Ronald L. ; Wallace, Robert B. ; Hageman, Gregory S. ; Chappell, Rick ; Blodi, Barbara A. ; Klein, Michael L. ; Gehrs, Karen M. ; Sarto, Gloria E. ; Mares, Julie A. / Vitamin D status and early age-related macular degeneration in postmenopausal women. In: Archives of Ophthalmology. 2011 ; Vol. 129, No. 4. pp. 481-489.
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abstract = "Objective: The relationship between serum 25-hydroxyvitamin D (25[OH]D) concentrations (nmol/L) and the prevalence of early age-related macular degeneration (AMD) was investigated in participants of the Carotenoids in Age-Related Eye Disease Study. Methods: Stereoscopic fundus photographs, taken from 2001 to 2004, assessed AMD status. Baseline (1994-1998) serum samples were available for 25(OH)D assays in 1313 women with complete ocular and risk factor data. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) for early AMD (n=241) of 1287 without advanced disease were estimated with logistic regression and adjusted for age, smoking, iris pigmentation, family history of AMD, cardiovascular disease, diabetes, and hormone therapy use. Results: In multivariate models, no significant relationship was observed between earlyAMDand 25(OH)D (OR for quintile 5 vs 1, 0.79; 95{\%} CI, 0.50-1.24; P for trend=.47). A significant age interaction (P=.002) suggested selective mortality bias in women aged 75 years and older: serum 25(OH)D was associated with decreased odds of early AMD in women younger than 75 years (n=968) and increased odds in women aged 75 years or older (n=319) (OR for quintile 5 vs 1, 0.52; 95{\%} CI, 0.29-0.91; P for trend=.02 and OR, 1.76; 95{\%} CI, 0.77-4.13; P for trend=.05, respectively). Further adjustment for body mass index and recreational physical activity, predictors of 25(OH)D, attenuated the observed association in women younger than 75 years. Additionally, among women younger than 75 years, intake of vitamin D from foods and supplements was related to decreased odds of early AMD in multivariate models; no relationship was observed with self-reported time spent in direct sunlight. Conclusions: High serum 25(OH)D concentrations may protect against early AMD in women younger than 75 years.",
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AU - Horst, Ronald L.

AU - Wallace, Robert B.

AU - Hageman, Gregory S.

AU - Chappell, Rick

AU - Blodi, Barbara A.

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