Vitamin D deficiency is associated with increased risk of non-alcoholic steatohepatitis in adults with non-alcoholic fatty liver disease

Possible role for MAPK and NF-κB?

James E. Nelson, Christian L. Roth, Laura A. Wilson, Katherine P. Yates, Bradley Aouizerat, Vicki Morgan-Stevenson, Elizabeth Whalen, Andrew Hoofnagle, Michael Mason, Vivian Gersuk, Matthew M. Yeh, Kris V. Kowdley

Research output: Contribution to journalArticle

Abstract

Objectives: The objective of this study was to determine the relationship of serum vitamin D deficiency (VDD) to histologic features of non-alcoholic fatty liver disease (NAFLD), and associated demographic, clinical, laboratory, and transcriptomic data in the well-characterized Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN) cohort. METHODS: Serum vitamin D 25(OH)D (VD) was quantified by liquid chromatography-tandem mass spectrometry in 190 adults (>18 years) with biopsy-proven NAFLD. Subjects were categorized according to their level of VD as either sufficient (>30 ng/ml), insufficient (≥20≤30 ng/ml), or deficient (VDD;

Original languageEnglish (US)
Pages (from-to)852-863
Number of pages12
JournalAmerican Journal of Gastroenterology
Volume111
Issue number6
DOIs
StatePublished - Jun 1 2016

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Vitamin D Deficiency
Fatty Liver
Tandem Mass Spectrometry
Serum
Vitamin D
Liquid Chromatography
Demography
Biopsy
Research
Non-alcoholic Fatty Liver Disease

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Vitamin D deficiency is associated with increased risk of non-alcoholic steatohepatitis in adults with non-alcoholic fatty liver disease : Possible role for MAPK and NF-κB? / Nelson, James E.; Roth, Christian L.; Wilson, Laura A.; Yates, Katherine P.; Aouizerat, Bradley; Morgan-Stevenson, Vicki; Whalen, Elizabeth; Hoofnagle, Andrew; Mason, Michael; Gersuk, Vivian; Yeh, Matthew M.; Kowdley, Kris V.

In: American Journal of Gastroenterology, Vol. 111, No. 6, 01.06.2016, p. 852-863.

Research output: Contribution to journalArticle

Nelson, JE, Roth, CL, Wilson, LA, Yates, KP, Aouizerat, B, Morgan-Stevenson, V, Whalen, E, Hoofnagle, A, Mason, M, Gersuk, V, Yeh, MM & Kowdley, KV 2016, 'Vitamin D deficiency is associated with increased risk of non-alcoholic steatohepatitis in adults with non-alcoholic fatty liver disease: Possible role for MAPK and NF-κB?', American Journal of Gastroenterology, vol. 111, no. 6, pp. 852-863. https://doi.org/10.1038/ajg.2016.51
Nelson, James E. ; Roth, Christian L. ; Wilson, Laura A. ; Yates, Katherine P. ; Aouizerat, Bradley ; Morgan-Stevenson, Vicki ; Whalen, Elizabeth ; Hoofnagle, Andrew ; Mason, Michael ; Gersuk, Vivian ; Yeh, Matthew M. ; Kowdley, Kris V. / Vitamin D deficiency is associated with increased risk of non-alcoholic steatohepatitis in adults with non-alcoholic fatty liver disease : Possible role for MAPK and NF-κB?. In: American Journal of Gastroenterology. 2016 ; Vol. 111, No. 6. pp. 852-863.
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AU - Wilson, Laura A.

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AU - Whalen, Elizabeth

AU - Hoofnagle, Andrew

AU - Mason, Michael

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