Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

Elizabeth A. Anderson, Steven Isaacman, David S. Peabody, Edwin Y. Wang, James Canary, Kent Kirshenbaum

Research output: Contribution to journalArticle

Abstract

A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T 1 relaxivities up to 7200 mM -1s -1 per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd 3+ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.

Original languageEnglish (US)
Pages (from-to)1160-1164
Number of pages5
JournalNano Letters
Volume6
Issue number6
DOIs
StatePublished - Jun 2006

Fingerprint

Magnetic resonance
conjugation
chelates
Contrast Media
magnetic resonance
Nanoparticles
Imaging techniques
Barreling
nanoparticles
Gadolinium
gadolinium
Fluorescein
assemblies
engineering
proteins
Proteins

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Viral nanoparticles donning a paramagnetic coat : Conjugation of MRI contrast agents to the MS2 capsid. / Anderson, Elizabeth A.; Isaacman, Steven; Peabody, David S.; Wang, Edwin Y.; Canary, James; Kirshenbaum, Kent.

In: Nano Letters, Vol. 6, No. 6, 06.2006, p. 1160-1164.

Research output: Contribution to journalArticle

Anderson, Elizabeth A. ; Isaacman, Steven ; Peabody, David S. ; Wang, Edwin Y. ; Canary, James ; Kirshenbaum, Kent. / Viral nanoparticles donning a paramagnetic coat : Conjugation of MRI contrast agents to the MS2 capsid. In: Nano Letters. 2006 ; Vol. 6, No. 6. pp. 1160-1164.
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