Variation in optical coherence tomography signal quality as an indicator of retinal nerve fibre layer segmentation error

Lindsey S. Folio, Gadi Wollstein, Hiroshi Ishikawa, Richard A. Bilonick, Yun Ling, Larry Kagemann, Robert J. Noecker, James G. Fujimoto, Joel S. Schuman

    Research output: Contribution to journalArticle

    Abstract

    Purpose: Commercial optical coherence tomography (OCT) systems use global signal quality indices to quantify scan quality. Signal quality can vary throughout a scan, contributing to local retinal nerve fibre layer segmentation errors (SegE). The purpose of this study was to develop an automated method, using local scan quality, to predict SegE. Methods: Good-quality (global signal strength (SS)≥6; manufacturer specification) peripapillary circular OCT scans (fast retinal nerve fibre layer scan protocol; Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA) were obtained from 6 healthy, 19 glaucoma-suspect and 43 glaucoma subjects. Scans were grouped based on SegE. Quality index (QI) values were computed for each A-scan using software of our own design. Logistic mixed-effects regression modelling was applied to evaluate SS, global mean and SD of QI, and the probability of SegE. Results: The difference between local mean QI in SegE regions and No-SegE regions was -5.06 (95% CI -6.38 to 3.734) (p<0.001). Using global mean QI, QI SD and their interaction term resulted in the model of best fit (Akaike information criterion=191.8) for predicting SegE. Global mean QI≥20 or SS≥8 shows little chance for SegE. Once mean QI<20 or SS<8, the probability of SegE increases as QI SD increases. Conclusions: When combined with a signal quality parameter, the variation of signal quality between A-scans provides significant information about the quality of an OCT scan and can be used as a predictor of segmentation error.

    Original languageEnglish (US)
    Pages (from-to)514-518
    Number of pages5
    JournalBritish Journal of Ophthalmology
    Volume96
    Issue number4
    DOIs
    StatePublished - Apr 1 2012

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems
    • Cellular and Molecular Neuroscience

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    Folio, L. S., Wollstein, G., Ishikawa, H., Bilonick, R. A., Ling, Y., Kagemann, L., Noecker, R. J., Fujimoto, J. G., & Schuman, J. S. (2012). Variation in optical coherence tomography signal quality as an indicator of retinal nerve fibre layer segmentation error. British Journal of Ophthalmology, 96(4), 514-518. https://doi.org/10.1136/bjophthalmol-2011-300044