Valence-dependent influence of serotonin depletion on model-based choice strategy

Y. Worbe, S. Palminteri, G. Savulich, N. D. Daw, E. Fernandez-Egea, T. W. Robbins, V. Voon

Research output: Contribution to journalArticle

Abstract

Human decision-making arises from both reflective and reflexive mechanisms, which underpin goal-directed and habitual behavioural control. Computationally, these two systems of behavioural control have been described by different learning algorithms, model-based and model-free learning, respectively. Here, we investigated the effect of diminished serotonin (5-hydroxytryptamine) neurotransmission using dietary tryptophan depletion (TD) in healthy volunteers on the performance of a two-stage decision-making task, which allows discrimination between model-free and model-based behavioural strategies. A novel version of the task was used, which not only examined choice balance for monetary reward but also for punishment (monetary loss). TD impaired goal-directed (model-based) behaviour in the reward condition, but promoted it under punishment. This effect on appetitive and aversive goal-directed behaviour is likely mediated by alteration of the average reward representation produced by TD, which is consistent with previous studies. Overall, the major implication of this study is that serotonin differentially affects goal-directed learning as a function of affective valence. These findings are relevant for a further understanding of psychiatric disorders associated with breakdown of goal-directed behavioural control such as obsessive-compulsive disorders or addictions.Molecular Psychiatry advance online publication, 14 April 2015; doi:10.1038/mp.2015.46.

Original languageEnglish (US)
JournalMolecular Psychiatry
DOIs
StateAccepted/In press - Apr 14 2015

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Serotonin
Reward
Tryptophan
Punishment
Learning
Psychiatry
Decision Making
Obsessive-Compulsive Disorder
Synaptic Transmission
Publications
Healthy Volunteers

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Worbe, Y., Palminteri, S., Savulich, G., Daw, N. D., Fernandez-Egea, E., Robbins, T. W., & Voon, V. (Accepted/In press). Valence-dependent influence of serotonin depletion on model-based choice strategy. Molecular Psychiatry. https://doi.org/10.1038/mp.2015.46

Valence-dependent influence of serotonin depletion on model-based choice strategy. / Worbe, Y.; Palminteri, S.; Savulich, G.; Daw, N. D.; Fernandez-Egea, E.; Robbins, T. W.; Voon, V.

In: Molecular Psychiatry, 14.04.2015.

Research output: Contribution to journalArticle

Worbe, Y, Palminteri, S, Savulich, G, Daw, ND, Fernandez-Egea, E, Robbins, TW & Voon, V 2015, 'Valence-dependent influence of serotonin depletion on model-based choice strategy', Molecular Psychiatry. https://doi.org/10.1038/mp.2015.46
Worbe Y, Palminteri S, Savulich G, Daw ND, Fernandez-Egea E, Robbins TW et al. Valence-dependent influence of serotonin depletion on model-based choice strategy. Molecular Psychiatry. 2015 Apr 14. https://doi.org/10.1038/mp.2015.46
Worbe, Y. ; Palminteri, S. ; Savulich, G. ; Daw, N. D. ; Fernandez-Egea, E. ; Robbins, T. W. ; Voon, V. / Valence-dependent influence of serotonin depletion on model-based choice strategy. In: Molecular Psychiatry. 2015.
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