Use of multiple sensitivity measurements and log it statistical analysis to assess the effectiveness of a potassium‐citrate‐containing dentifrice in reducing dentinal hypersensitivity

R. Chesters, H. W. Kaufman, M. S. Wolff, E. Hunungton, I. Kleinberg

Research output: Contribution to journalArticle


Abstract A potassium citrate‐SMFP containing dentifrice was tested in double‐blind 8‐week clinical trial on subjects with a history of dentinal hypersensitivity. A dentifrice containing SMFP but no potassium salt was used as the control and a 2nd test dentifrice containing potassium nitrate‐SMFP was assessed at the same time. The sensitivity of the subjects was evaluated at 0, 3 and 8 weeks using electrical and tactile methods plus a 1‐s air blast. The sensitivity scores for each subject at each examination were summarised as a proportion of the examined teeth deemed sensitive. Assessment of any effects of the dentifrices was via an analysis of covariance of the logit transformation of these proportions with the baseline value as the covariate. The use of this novel method of analysis had the advantage of taking into account changes in sensitivity of alt of the teeth, both sensitive and non‐sensitive, since electrical measurements indicated effects on both. Of the original 120 subjects. 111 completed the trial and the 3 dentifrice groups remained well balanced for age, sex and sensitivity. All 3 dentifrice groups showed statistically significant reductions in sensitivity over the 8 weeks. However, the potassium citrate‐SMFP dentifrice was significantly more effective than either the control SMFP dentifrice, or the potassium nitrate‐SMFP dentifrice, at reducing sensitivity after 3 weeks, and this difference plus further sensitivity reduction with all 3 dentifrices was observed after 8 weeks.

Original languageEnglish (US)
Pages (from-to)256-261
Number of pages6
JournalJournal of Clinical Periodontology
Issue number4
StatePublished - Apr 1992



  • dentinal hypersensitivity
  • potassium citrate
  • potassium nitrate
  • sodium monofluorophosphate

ASJC Scopus subject areas

  • Periodontics

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