Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control

Glenn Dallérac, Michael Graupner, Jeroen Knippenberg, Raquel Chacon Ruiz Martinez, Tatiane Ferreira Tavares, Lucille Tallot, Nicole El Massioui, Anna Verschueren, Sophie Höhn, Julie Boulanger Bertolus, Alexander Reyes, Joseph Ledoux, Glenn E. Schafe, Lorenzo Diaz-Mataix, Valerie Doyère

Research output: Contribution to journalArticle

Abstract

Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala.

Original languageEnglish (US)
Article number13920
JournalNature Communications
Volume8
DOIs
StatePublished - Jan 9 2017

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Corpus Striatum
Amygdala
plastic properties
stimuli
Plasticity
Rats
intervals
Association Learning
Learning
Theta Rhythm
conditioning (learning)
learning
rhythm
potential fields
rats
coding
time measurement

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Dallérac, G., Graupner, M., Knippenberg, J., Martinez, R. C. R., Tavares, T. F., Tallot, L., ... Doyère, V. (2017). Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. Nature Communications, 8, [13920]. https://doi.org/10.1038/ncomms13920

Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. / Dallérac, Glenn; Graupner, Michael; Knippenberg, Jeroen; Martinez, Raquel Chacon Ruiz; Tavares, Tatiane Ferreira; Tallot, Lucille; El Massioui, Nicole; Verschueren, Anna; Höhn, Sophie; Bertolus, Julie Boulanger; Reyes, Alexander; Ledoux, Joseph; Schafe, Glenn E.; Diaz-Mataix, Lorenzo; Doyère, Valerie.

In: Nature Communications, Vol. 8, 13920, 09.01.2017.

Research output: Contribution to journalArticle

Dallérac, G, Graupner, M, Knippenberg, J, Martinez, RCR, Tavares, TF, Tallot, L, El Massioui, N, Verschueren, A, Höhn, S, Bertolus, JB, Reyes, A, Ledoux, J, Schafe, GE, Diaz-Mataix, L & Doyère, V 2017, 'Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control', Nature Communications, vol. 8, 13920. https://doi.org/10.1038/ncomms13920
Dallérac G, Graupner M, Knippenberg J, Martinez RCR, Tavares TF, Tallot L et al. Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. Nature Communications. 2017 Jan 9;8. 13920. https://doi.org/10.1038/ncomms13920
Dallérac, Glenn ; Graupner, Michael ; Knippenberg, Jeroen ; Martinez, Raquel Chacon Ruiz ; Tavares, Tatiane Ferreira ; Tallot, Lucille ; El Massioui, Nicole ; Verschueren, Anna ; Höhn, Sophie ; Bertolus, Julie Boulanger ; Reyes, Alexander ; Ledoux, Joseph ; Schafe, Glenn E. ; Diaz-Mataix, Lorenzo ; Doyère, Valerie. / Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. In: Nature Communications. 2017 ; Vol. 8.
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