Unsupervised learning of spike patterns for seizure detection and wavefront estimation of high resolution micro electrocorticographic (μ ECoG) data

Yilin Song, Yao Wang, Jonathan Viventi

Research output: Contribution to journalArticle


For the past few years, we have developed flexible, active, and multiplexed recording devices for high resolution recording over large, clinically relevant areas in the brain. While this technology has enabled a much higher-resolution view of the electrical activity of the brain, the analytical methods to process, categorize, and respond to the huge volumes of seizure data produced by these devices have not yet been developed. In this paper, we proposed an unsupervised learning framework for spike analysis, which by itself reveals spike pattern. By applying advanced video processing techniques for separating a multi-channel recording into individual spike segments, unfolding the spike segments manifold, and identifying natural clusters for spike patterns, we are able to find the common spike motion patterns. And we further explored using these patterns for more interesting and practical problems as seizure prediction and spike wavefront prediction. These methods have been applied to in vivo feline seizure recordings and yielded promising results.

Original languageEnglish (US)
Article number7945476
Pages (from-to)418-427
Number of pages10
JournalIEEE Transactions on Nanobioscience
Issue number6
StatePublished - Sep 2017



  • Clustering
  • manifold
  • seizure detection
  • wavefront prediction

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science
  • Computer Science Applications
  • Electrical and Electronic Engineering

Cite this