Unprecedented sodium-oxygen clusters in the solid-state structure of trisodium hydrogentetravalproate monohydrate: A model for the physiological activity of the anticonvulsant drug Epilim®

Gjorgi Petruševski, Pance Naumov, Gligor Jovanovski, Seik Weng Ng

Research output: Contribution to journalArticle

Abstract

The first crystal structure determination of one of the solid forms of sodium valproate revealed that the crystal is a 3:1 solvate of sodium valproate and valproic acid. The anion symmetry-directed formation of stable sodium-oxygen clusters protected by alkyl layer which can act as lipophilic micelles may be important for understanding the strong anticonvulsant activity of the valproate ion.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalInorganic Chemistry Communications
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2008

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anticonvulsants
Valproic Acid
Anticonvulsants
drugs
Sodium
sodium
Oxygen
solid state
oxygen
Micelles
micelles
Negative ions
Crystal structure
anions
Anions
Crystals
acids
crystal structure
Acids
Ions

Keywords

  • Anticonvulsants
  • Bilayers
  • Clusters
  • Epilim
  • Hydrates
  • Hygroscopicity

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

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abstract = "The first crystal structure determination of one of the solid forms of sodium valproate revealed that the crystal is a 3:1 solvate of sodium valproate and valproic acid. The anion symmetry-directed formation of stable sodium-oxygen clusters protected by alkyl layer which can act as lipophilic micelles may be important for understanding the strong anticonvulsant activity of the valproate ion.",
keywords = "Anticonvulsants, Bilayers, Clusters, Epilim, Hydrates, Hygroscopicity",
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T1 - Unprecedented sodium-oxygen clusters in the solid-state structure of trisodium hydrogentetravalproate monohydrate

T2 - A model for the physiological activity of the anticonvulsant drug Epilim®

AU - Petruševski, Gjorgi

AU - Naumov, Pance

AU - Jovanovski, Gligor

AU - Ng, Seik Weng

PY - 2008/1/1

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N2 - The first crystal structure determination of one of the solid forms of sodium valproate revealed that the crystal is a 3:1 solvate of sodium valproate and valproic acid. The anion symmetry-directed formation of stable sodium-oxygen clusters protected by alkyl layer which can act as lipophilic micelles may be important for understanding the strong anticonvulsant activity of the valproate ion.

AB - The first crystal structure determination of one of the solid forms of sodium valproate revealed that the crystal is a 3:1 solvate of sodium valproate and valproic acid. The anion symmetry-directed formation of stable sodium-oxygen clusters protected by alkyl layer which can act as lipophilic micelles may be important for understanding the strong anticonvulsant activity of the valproate ion.

KW - Anticonvulsants

KW - Bilayers

KW - Clusters

KW - Epilim

KW - Hydrates

KW - Hygroscopicity

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JF - Inorganic Chemistry Communication

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