Universal protein distributions in a model of cell growth and division

Naama Brenner, C. M. Newman, Dino Osmanovic, Yitzhak Rabin, Hanna Salman, D. L. Stein

Research output: Contribution to journalArticle

Abstract

Protein distributions measured under a broad set of conditions in bacteria and yeast were shown to exhibit a common skewed shape, with variances depending quadratically on means. For bacteria these properties were reproduced by temporal measurements of protein content, showing accumulation and division across generations. Here we present a stochastic growth-and-division model with feedback which captures these observed properties. The limiting copy number distribution is calculated exactly, and a single parameter is found to determine the distribution shape and the variance-to-mean relation. Estimating this parameter from bacterial temporal data reproduces the measured distribution shape with high accuracy, and leads to predictions for future experiments.
Original languageUndefined
Article number1504.02139
JournalarXiv
DOIs
StatePublished - Apr 8 2015

Keywords

  • physics.bio-ph
  • q-bio.SC

Cite this

Brenner, N., Newman, C. M., Osmanovic, D., Rabin, Y., Salman, H., & Stein, D. L. (2015). Universal protein distributions in a model of cell growth and division. arXiv, [1504.02139]. https://doi.org/10.1103/PhysRevE.92.042713

Universal protein distributions in a model of cell growth and division. / Brenner, Naama; Newman, C. M.; Osmanovic, Dino; Rabin, Yitzhak; Salman, Hanna; Stein, D. L.

In: arXiv, 08.04.2015.

Research output: Contribution to journalArticle

Brenner, Naama ; Newman, C. M. ; Osmanovic, Dino ; Rabin, Yitzhak ; Salman, Hanna ; Stein, D. L. / Universal protein distributions in a model of cell growth and division. In: arXiv. 2015.
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