Universal curve, biological time, and dynamically varying scaling exponent in growth law

Luciano Medina, Yisong Yang

Research output: Contribution to journalArticle

Abstract

A general quantitative model for ontogenetic growth of organisms was derived by West et al. based on fundamental principles for the allocation of metabolic energy in which a universal parameterless growth curve was established in terms of the biomass ratio and a dimensionless biological time. This model was then extended by Guiot et al. to account for the growth of tumors in vivo in which the fractional scaling exponent p becomes a dynamic parameter depending on time t. In this paper, we present a method that may be used effectively to construct a generalized universal growth curve for such a growth law model with an arbitrary dynamically varying fractional exponent. As by-products of this method, we show that the assumption that a biological time variable flows forward in the universal curve allows us to predict the behavior of p with regard to the developmental stages of organisms characterized by body mass which is consistent with the findings of Guiot et al. based on biomedical data, and that, the universal curve is independent of the properties of p as a function of t. We also consider the situation when time increases discretely and the fractional scaling exponent is periodic. We observe the familiar, but superimposed, period-doubling and transition-to-chaos phenomenon.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalNonlinear Analysis: Real World Applications
Volume11
Issue number1
DOIs
StatePublished - Feb 2010

Fingerprint

Scaling Exponent
Growth Curve
Curve
Fractional
Growth
Period Doubling
Biomass
Dimensionless
Tumor
Chaos
Chaos theory
Exponent
Model
Byproducts
Tumors
Predict
Scaling
Arbitrary
Energy
Neoplasms

Keywords

  • Chaos
  • Convergence
  • Dynamical dependence
  • Growth model
  • Period-doubling
  • Transition of stability
  • Universality

ASJC Scopus subject areas

  • Analysis
  • Applied Mathematics
  • Computational Mathematics
  • Engineering(all)
  • Medicine(all)
  • Economics, Econometrics and Finance(all)

Cite this

Universal curve, biological time, and dynamically varying scaling exponent in growth law. / Medina, Luciano; Yang, Yisong.

In: Nonlinear Analysis: Real World Applications, Vol. 11, No. 1, 02.2010, p. 391-400.

Research output: Contribution to journalArticle

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