Uniform magnetization transfer in chemical exchange saturation transfer magnetic resonance imaging

Jae Seung Lee, Prodromos Parasoglou, Ding Xia, Alexej Jerschow, Ravinder R. Regatte

Research output: Contribution to journalArticle

Abstract

The development of chemical exchange saturation transfer (CEST) has led to the establishment of new contrast mechanisms in magnetic resonance imaging, which serve as enablers for advanced molecular imaging strategies. Macromolecules in tissues and organs often give rise to broad and asymmetric exchange effects, called magnetization transfer (MT) effects, which can mask the CEST contrast of interest. We show here that the saturation of these macromolecular pools simultaneously at two distinct frequencies can level out the asymmetric MT effects, thus allowing one to isolate the CEST effects in vivo. For the first time, clean CEST contrast for glycosaminoglycans (gagCEST) in cartilage in the human knee joint is presented. In addition, the method allows one to clearly demarcate glycosaminoglycan measurements from cartilage and synovial fluid regions. This uniform-MT CEST methodology has wide applicability in in vivo molecular imaging (such as brain, skeletal muscle, etc).

Original languageEnglish (US)
Article number1707
JournalScientific Reports
Volume3
DOIs
StatePublished - 2013

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Molecular Imaging
Glycosaminoglycans
Cartilage
Magnetic Resonance Imaging
Synovial Fluid
Masks
Knee Joint
Skeletal Muscle
Brain

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Uniform magnetization transfer in chemical exchange saturation transfer magnetic resonance imaging. / Lee, Jae Seung; Parasoglou, Prodromos; Xia, Ding; Jerschow, Alexej; Regatte, Ravinder R.

In: Scientific Reports, Vol. 3, 1707, 2013.

Research output: Contribution to journalArticle

Lee, Jae Seung ; Parasoglou, Prodromos ; Xia, Ding ; Jerschow, Alexej ; Regatte, Ravinder R. / Uniform magnetization transfer in chemical exchange saturation transfer magnetic resonance imaging. In: Scientific Reports. 2013 ; Vol. 3.
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