Understanding parathyroid hormone action

Nicola C. Partridge, Xin Li, Ling Qin

Research output: Contribution to journalArticle

Abstract

In addition to regulating serum calcium and stimulating bone resorption, parathyroid hormone (PTH) is known to stimulate bone formation under certain conditions. The mechanisms behind this counterintuitive anabolic action are largely unknown. We have set out to identify PTH-regulated genes that might be responsible for each of these contrasting effects of the hormone. This article describes our work on a select number of those genes.

Original languageEnglish (US)
Pages (from-to)187-193
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1068
Issue number1
DOIs
StatePublished - Apr 2006

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Keywords

  • Amphiregulin
  • Bone formation
  • Bone resorption
  • EGF
  • MCP-1
  • Osteoblast
  • PTH
  • Parathyroid hormone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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