Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser

S. I. Shopova, R. Rajmangal, Y. Nishida, S. Arnold

Research output: Contribution to journalArticle

Abstract

We demonstrate a significant reduction in the limit of label-free detection of individual viral-sized nanoparticles in aqueous solution through the use of a frequency doubled telecom laser constructed from a distributed feedback-periodically poled lithium-niobate (DFB-PPLN) union. By driving a whispering gallery mode biosensor near a wavelength of 650 nm with this device we have detected real-time adsorption steps for particles 36 nm in radius with a signal to noise ratio of 8. The noise equivalent detection limit is ∼20 ag (17 nm radius). This new lower limit is attributed to the ultralow resonance wavelength noise [(Δ λr) rms / λr < 10-9] associated with the use of the DFB-PPLN device.

Original languageEnglish (US)
Article number103110
JournalReview of Scientific Instruments
Volume81
Issue number10
DOIs
StatePublished - Oct 2010

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Whispering gallery modes
whispering gallery modes
Distributed feedback lasers
distributed feedback lasers
Biosensing Techniques
lithium niobates
bioinstrumentation
Biosensors
Nanoparticles
Noise
Lasers
Lithium
Feedback
Equipment and Supplies
Wavelength
nanoparticles
Signal-To-Noise Ratio
Adsorption
Limit of Detection
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ASJC Scopus subject areas

  • Instrumentation
  • Medicine(all)

Cite this

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abstract = "We demonstrate a significant reduction in the limit of label-free detection of individual viral-sized nanoparticles in aqueous solution through the use of a frequency doubled telecom laser constructed from a distributed feedback-periodically poled lithium-niobate (DFB-PPLN) union. By driving a whispering gallery mode biosensor near a wavelength of 650 nm with this device we have detected real-time adsorption steps for particles 36 nm in radius with a signal to noise ratio of 8. The noise equivalent detection limit is ∼20 ag (17 nm radius). This new lower limit is attributed to the ultralow resonance wavelength noise [(Δ λr) rms / λr < 10-9] associated with the use of the DFB-PPLN device.",
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AU - Arnold, S.

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AB - We demonstrate a significant reduction in the limit of label-free detection of individual viral-sized nanoparticles in aqueous solution through the use of a frequency doubled telecom laser constructed from a distributed feedback-periodically poled lithium-niobate (DFB-PPLN) union. By driving a whispering gallery mode biosensor near a wavelength of 650 nm with this device we have detected real-time adsorption steps for particles 36 nm in radius with a signal to noise ratio of 8. The noise equivalent detection limit is ∼20 ag (17 nm radius). This new lower limit is attributed to the ultralow resonance wavelength noise [(Δ λr) rms / λr < 10-9] associated with the use of the DFB-PPLN device.

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