U50,488 increases ultrasonic vocalizations in 3-, 10-, and 18-day-old rat pups in isolation and the home cage.

S. E. Carden, Lila Davachi, M. A. Hofer

Research output: Contribution to journalArticle

Abstract

Separation-induced calling in the young of many species can be modulated by the opioid system. Morphine reduces ultrasonic vocalizations (USVs) produced by isolated rat pups, an effect blocked by naltrexone. Central administration of the mu and delta opiate receptor agonists DAMGO and DPDPE reduce USV; kappa receptor agonist U50,488 increases them. We now find that peripheral U50,488 not only boosted calling rates in isolated 3-, 10-, and 18-day-old rat pups, but also induced calling in pups of these ages tested in the home cage with their littermates, where USVs are seldom heard in nature. U50,488 lowered rectal temperature, although temperature loss and USV were not correlated within drug treatment groups.

Original languageEnglish (US)
Pages (from-to)65-83
Number of pages19
JournalDevelopmental Psychobiology
Volume27
Issue number1
StatePublished - Jan 1994

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Ultrasonics
D-Penicillamine (2,5)-Enkephalin
Ala(2)-MePhe(4)-Gly(5)-enkephalin
kappa Opioid Receptor
Naltrexone
delta Opioid Receptor
Temperature
Opioid Receptors
Morphine
Opioid Analgesics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Psychology(all)

Cite this

U50,488 increases ultrasonic vocalizations in 3-, 10-, and 18-day-old rat pups in isolation and the home cage. / Carden, S. E.; Davachi, Lila; Hofer, M. A.

In: Developmental Psychobiology, Vol. 27, No. 1, 01.1994, p. 65-83.

Research output: Contribution to journalArticle

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