Tyrosine phosphatases

Cellular functions and therapeutic potential

A. G. Klann, R. A. Miller, E. D. Norman, Eric Klann

Research output: Contribution to journalArticle

Abstract

Proper control of protein tyrosine phosphorylation, a post-translational modification that is critical for cell growth and differentiation, is accomplished through the actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Alterations in the activity of either of these enzymes can result in improper protein tyrosine phosphorylation which can lead to oncogenic transformation of cells. This review summarises recent advances in the identification and characterisation of protein tyrosine phosphatases and the patent literature related to these advances.

Original languageEnglish (US)
Pages (from-to)675-683
Number of pages9
JournalExpert Opinion on Therapeutic Patents
Volume10
Issue number5
StatePublished - 2000

Fingerprint

Protein Tyrosine Phosphatases
Phosphoric Monoester Hydrolases
Tyrosine
Phosphorylation
Literature
Patents
Post Translational Protein Processing
patent
Protein-Tyrosine Kinases
Cell Differentiation
Proteins
Enzymes
Therapeutics
Growth
literature

Keywords

  • Cancer
  • Dephosphorylation
  • Diabetes
  • Protein tyrosine phosphatase
  • Signalling

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Law

Cite this

Tyrosine phosphatases : Cellular functions and therapeutic potential. / Klann, A. G.; Miller, R. A.; Norman, E. D.; Klann, Eric.

In: Expert Opinion on Therapeutic Patents, Vol. 10, No. 5, 2000, p. 675-683.

Research output: Contribution to journalArticle

Klann, A. G. ; Miller, R. A. ; Norman, E. D. ; Klann, Eric. / Tyrosine phosphatases : Cellular functions and therapeutic potential. In: Expert Opinion on Therapeutic Patents. 2000 ; Vol. 10, No. 5. pp. 675-683.
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