Tyrosine kinases, synaptic plasticity and memory: Insights from vertebrates and invertebrates

Angela L. Purcell, Thomas Carew

Research output: Contribution to journalArticle

Abstract

Tyrosine kinases were first characterized in terms of their function during development. Over the past decade, it has become clear that tyrosine phosphorylation also plays an important role in the adult mammalian nervous system. This article reviews three different families of tyrosine kinase signaling cascades: the Trk receptor tyrosine kinases, the Src family of non-receptor tyrosine kinases and the Eph receptor tyrosine kinases. Each of these cascades has been implicated in both adult synaptic plasticity and memory formation. Evidence from invertebrate systems also demonstrates a role for tyrosine kinase signaling in the induction of long-term memory, suggesting that molecular mechanisms of memory formation are conserved across species.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalTrends in Neurosciences
Volume26
Issue number11
DOIs
StatePublished - Nov 2003

Fingerprint

Neuronal Plasticity
Invertebrates
Protein-Tyrosine Kinases
Vertebrates
Eph Family Receptors
Long-Term Memory
src-Family Kinases
Receptor Protein-Tyrosine Kinases
Nervous System
Tyrosine
Phosphorylation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tyrosine kinases, synaptic plasticity and memory : Insights from vertebrates and invertebrates. / Purcell, Angela L.; Carew, Thomas.

In: Trends in Neurosciences, Vol. 26, No. 11, 11.2003, p. 625-630.

Research output: Contribution to journalArticle

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