Types of tobacco consumption and the oral microbiome in the United Arab Emirates Healthy Future (UAEHFS) Pilot Study

Yvonne Vallès, Claire K. Inman, Brandilyn A. Peters, Raghib Ali, Laila Abdel Wareth, Abdishakur Abdulle, Habiba Alsafar, Fatme Al Anouti, Ayesha Al Dhaheri, Divya Galani, Muna Haji, Aisha Al Hamiz, Ayesha Al Hosani, Mohammed Al Houqani, Abdulla Al Junaibi, Marina Kazim, Tomas Kirchhoff, Wael Al Mahmeed, Fatma Al Maskari, Abdullah Alnaeemi & 8 others Naima Oumeziane, Ravichandran Ramasamy, Ann Marie Schmidt, Michael Weitzman, Eiman Al Zaabi, Scott Sherman, Richard B. Hayes, Jiyoung Ahn

    Research output: Contribution to journalArticle

    Abstract

    Cigarette smoking alters the oral microbiome; however, the effect of alternative tobacco products remains unclear. Middle Eastern tobacco products like dokha and shisha, are becoming globally widespread. We tested for the first time in a Middle Eastern population the hypothesis that different tobacco products impact the oral microbiome. The oral microbiome of 330 subjects from the United Arab Emirates Healthy Future Study was assessed by amplifying the bacterial 16S rRNA gene from mouthwash samples. Tobacco consumption was assessed using a structured questionnaire and further validated by urine cotinine levels. Oral microbiome overall structure and specific taxon abundances were compared, using PERMANOVA and DESeq analyses respectively. Our results show that overall microbial composition differs between smokers and nonsmokers (p = 0.0001). Use of cigarettes (p = 0.001) and dokha (p = 0.042) were associated with overall microbiome structure, while shisha use was not (p = 0.62). The abundance of multiple genera were significantly altered (enriched/depleted) in cigarette smokers; however, only Actinobacillus, Porphyromonas, Lautropia and Bifidobacterium abundances were significantly changed in dokha users whereas no genera were significantly altered in shisha smokers. For the first time, we show that smoking dokha is associated to oral microbiome dysbiosis, suggesting that it could have similar effects as smoking cigarettes on oral health.

    Original languageEnglish (US)
    Article number11327
    JournalScientific Reports
    Volume8
    Issue number1
    DOIs
    StatePublished - Dec 1 2018

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    United Arab Emirates
    Microbiota
    Tobacco Use
    Tobacco Products
    Smoking
    Porphyromonas
    Actinobacillus
    Dysbiosis
    Mouthwashes
    Cotinine
    Bifidobacterium
    Oral Health
    rRNA Genes
    Urine
    Population

    ASJC Scopus subject areas

    • General

    Cite this

    Vallès, Y., Inman, C. K., Peters, B. A., Ali, R., Wareth, L. A., Abdulle, A., ... Ahn, J. (2018). Types of tobacco consumption and the oral microbiome in the United Arab Emirates Healthy Future (UAEHFS) Pilot Study. Scientific Reports, 8(1), [11327]. https://doi.org/10.1038/s41598-018-29730-x

    Types of tobacco consumption and the oral microbiome in the United Arab Emirates Healthy Future (UAEHFS) Pilot Study. / Vallès, Yvonne; Inman, Claire K.; Peters, Brandilyn A.; Ali, Raghib; Wareth, Laila Abdel; Abdulle, Abdishakur; Alsafar, Habiba; Anouti, Fatme Al; Dhaheri, Ayesha Al; Galani, Divya; Haji, Muna; Hamiz, Aisha Al; Hosani, Ayesha Al; Houqani, Mohammed Al; Junaibi, Abdulla Al; Kazim, Marina; Kirchhoff, Tomas; Mahmeed, Wael Al; Maskari, Fatma Al; Alnaeemi, Abdullah; Oumeziane, Naima; Ramasamy, Ravichandran; Schmidt, Ann Marie; Weitzman, Michael; Zaabi, Eiman Al; Sherman, Scott; Hayes, Richard B.; Ahn, Jiyoung.

    In: Scientific Reports, Vol. 8, No. 1, 11327, 01.12.2018.

    Research output: Contribution to journalArticle

    Vallès, Y, Inman, CK, Peters, BA, Ali, R, Wareth, LA, Abdulle, A, Alsafar, H, Anouti, FA, Dhaheri, AA, Galani, D, Haji, M, Hamiz, AA, Hosani, AA, Houqani, MA, Junaibi, AA, Kazim, M, Kirchhoff, T, Mahmeed, WA, Maskari, FA, Alnaeemi, A, Oumeziane, N, Ramasamy, R, Schmidt, AM, Weitzman, M, Zaabi, EA, Sherman, S, Hayes, RB & Ahn, J 2018, 'Types of tobacco consumption and the oral microbiome in the United Arab Emirates Healthy Future (UAEHFS) Pilot Study', Scientific Reports, vol. 8, no. 1, 11327. https://doi.org/10.1038/s41598-018-29730-x
    Vallès, Yvonne ; Inman, Claire K. ; Peters, Brandilyn A. ; Ali, Raghib ; Wareth, Laila Abdel ; Abdulle, Abdishakur ; Alsafar, Habiba ; Anouti, Fatme Al ; Dhaheri, Ayesha Al ; Galani, Divya ; Haji, Muna ; Hamiz, Aisha Al ; Hosani, Ayesha Al ; Houqani, Mohammed Al ; Junaibi, Abdulla Al ; Kazim, Marina ; Kirchhoff, Tomas ; Mahmeed, Wael Al ; Maskari, Fatma Al ; Alnaeemi, Abdullah ; Oumeziane, Naima ; Ramasamy, Ravichandran ; Schmidt, Ann Marie ; Weitzman, Michael ; Zaabi, Eiman Al ; Sherman, Scott ; Hayes, Richard B. ; Ahn, Jiyoung. / Types of tobacco consumption and the oral microbiome in the United Arab Emirates Healthy Future (UAEHFS) Pilot Study. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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    AU - Ali, Raghib

    AU - Wareth, Laila Abdel

    AU - Abdulle, Abdishakur

    AU - Alsafar, Habiba

    AU - Anouti, Fatme Al

    AU - Dhaheri, Ayesha Al

    AU - Galani, Divya

    AU - Haji, Muna

    AU - Hamiz, Aisha Al

    AU - Hosani, Ayesha Al

    AU - Houqani, Mohammed Al

    AU - Junaibi, Abdulla Al

    AU - Kazim, Marina

    AU - Kirchhoff, Tomas

    AU - Mahmeed, Wael Al

    AU - Maskari, Fatma Al

    AU - Alnaeemi, Abdullah

    AU - Oumeziane, Naima

    AU - Ramasamy, Ravichandran

    AU - Schmidt, Ann Marie

    AU - Weitzman, Michael

    AU - Zaabi, Eiman Al

    AU - Sherman, Scott

    AU - Hayes, Richard B.

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