Two mechanisms of isoproterenol inhibition of smooth muscle

Norbert I A Overweg, Joel Schiff

Research output: Contribution to journalArticle

Abstract

The relaxation of depolarized ileal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid β-adrenergic mechanism independent of cAMP as well as slower cAMP-dependent relaxation. This dual process model for β-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalEuropean Journal of Pharmacology
Volume47
Issue number2
DOIs
StatePublished - Jan 15 1978

Fingerprint

Isoproterenol
Adrenergic Agents
Smooth Muscle
Myometrium

Keywords

  • Cyclic AMP
  • Isoproterenol
  • Phosphodiesterase inhibitors
  • Smooth muscle

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Two mechanisms of isoproterenol inhibition of smooth muscle. / Overweg, Norbert I A; Schiff, Joel.

In: European Journal of Pharmacology, Vol. 47, No. 2, 15.01.1978, p. 231-233.

Research output: Contribution to journalArticle

@article{e0a073471b41419d9159bc14d9dd3a78,
title = "Two mechanisms of isoproterenol inhibition of smooth muscle",
abstract = "The relaxation of depolarized ileal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid β-adrenergic mechanism independent of cAMP as well as slower cAMP-dependent relaxation. This dual process model for β-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.",
keywords = "Cyclic AMP, Isoproterenol, Phosphodiesterase inhibitors, Smooth muscle",
author = "Overweg, {Norbert I A} and Joel Schiff",
year = "1978",
month = "1",
day = "15",
doi = "10.1016/0014-2999(78)90395-3",
language = "English (US)",
volume = "47",
pages = "231--233",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Two mechanisms of isoproterenol inhibition of smooth muscle

AU - Overweg, Norbert I A

AU - Schiff, Joel

PY - 1978/1/15

Y1 - 1978/1/15

N2 - The relaxation of depolarized ileal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid β-adrenergic mechanism independent of cAMP as well as slower cAMP-dependent relaxation. This dual process model for β-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.

AB - The relaxation of depolarized ileal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid β-adrenergic mechanism independent of cAMP as well as slower cAMP-dependent relaxation. This dual process model for β-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.

KW - Cyclic AMP

KW - Isoproterenol

KW - Phosphodiesterase inhibitors

KW - Smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=0017891403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017891403&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(78)90395-3

DO - 10.1016/0014-2999(78)90395-3

M3 - Article

C2 - 202471

AN - SCOPUS:0017891403

VL - 47

SP - 231

EP - 233

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -