Two different lateral amygdala cell populations contribute to the initiation and storage of memory

J. C. Repa, J. Muller, J. Apergis, T. M. Desrochers, Y. Zhou, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Single-cell activity was recorded in the dorsal subnucleus of the lateral amygdala (LAd) of freely behaving rats during Pavlovian fear conditioning, to determine the relationship between neuronal activity and behavioral learning. Neuronal responses elicited by the conditioned stimulus typically increased before behavioral fear was evident, supporting the hypothesis that neural changes in LAd account for the conditioning of behavior. Furthermore, two types of these rapidly modified cells were found. Some, located in the dorsal tip of LAd, exhibited short-latency responses (<20 ms) that were only transiently changed. A second class of cells, most commonly found in ventral regions of LAd, had longer latency responses, but maintained enhanced responding throughout training and even through extinction. These anatomically distinct cells in LAd may be differentially involved in the initiation of learning and long-term memory storage.

Original languageEnglish (US)
Pages (from-to)724-731
Number of pages8
JournalNature Neuroscience
Volume4
Issue number7
DOIs
StatePublished - 2001

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Amygdala
Population
Reaction Time
Fear
Learning
Long-Term Memory
Conditioning (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Two different lateral amygdala cell populations contribute to the initiation and storage of memory. / Repa, J. C.; Muller, J.; Apergis, J.; Desrochers, T. M.; Zhou, Y.; Ledoux, Joseph.

In: Nature Neuroscience, Vol. 4, No. 7, 2001, p. 724-731.

Research output: Contribution to journalArticle

Repa, J. C. ; Muller, J. ; Apergis, J. ; Desrochers, T. M. ; Zhou, Y. ; Ledoux, Joseph. / Two different lateral amygdala cell populations contribute to the initiation and storage of memory. In: Nature Neuroscience. 2001 ; Vol. 4, No. 7. pp. 724-731.
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