Two alternating motor programs drive navigation in Drosophila larva

Subhaneil Lahiri, Konlin Shen, Mason Klein, Anji Tang, Elizabeth Kane, Marc Gershow, Paul Garrity, Aravinthan D T Samuel

    Research output: Contribution to journalArticle

    Abstract

    When placed on a temperature gradient, a Drosophila larva navigates away from excessive cold or heat by regulating the size, frequency, and direction of reorientation maneuvers between successive periods of forward movement. Forward movement is driven by peristalsis waves that travel from tail to head. During each reorientation maneuver, the larva pauses and sweeps its head from side to side until it picks a new direction for forward movement. Here, we characterized the motor programs that underlie the initiation, execution, and completion of reorientation maneuvers by measuring body segment dynamics of freely moving larvae with fluorescent muscle fibers as they were exposed to temporal changes in temperature. We find that reorientation maneuvers are characterized by highly stereotyped spatiotemporal patterns of segment dynamics. Reorientation maneuvers are initiated with head sweeping movement driven by asymmetric contraction of a portion of anterior body segments. The larva attains a new direction for forward movement after head sweeping movement by using peristalsis waves that gradually push posterior body segments out of alignment with the tail (i.e., the previous direction of forward movement) into alignment with the head. Thus, reorientation maneuvers during thermotaxis are carried out by two alternating motor programs: (1) peristalsis for driving forward movement and (2) asymmetric contraction of anterior body segments for driving head sweeping movement.

    Original languageEnglish (US)
    Article numbere23180
    JournalPLoS One
    Volume6
    Issue number8
    DOIs
    StatePublished - 2011

    Fingerprint

    Peristalsis
    Head Movements
    Drosophila
    Larva
    Navigation
    peristalsis
    larvae
    Tail
    Head
    Temperature
    tail
    Thermal gradients
    Muscle
    Hot Temperature
    muscle fibers
    temperature profiles
    Muscles
    travel
    Direction compound
    Drive

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Lahiri, S., Shen, K., Klein, M., Tang, A., Kane, E., Gershow, M., ... Samuel, A. D. T. (2011). Two alternating motor programs drive navigation in Drosophila larva. PLoS One, 6(8), [e23180]. https://doi.org/10.1371/journal.pone.0023180

    Two alternating motor programs drive navigation in Drosophila larva. / Lahiri, Subhaneil; Shen, Konlin; Klein, Mason; Tang, Anji; Kane, Elizabeth; Gershow, Marc; Garrity, Paul; Samuel, Aravinthan D T.

    In: PLoS One, Vol. 6, No. 8, e23180, 2011.

    Research output: Contribution to journalArticle

    Lahiri, S, Shen, K, Klein, M, Tang, A, Kane, E, Gershow, M, Garrity, P & Samuel, ADT 2011, 'Two alternating motor programs drive navigation in Drosophila larva', PLoS One, vol. 6, no. 8, e23180. https://doi.org/10.1371/journal.pone.0023180
    Lahiri S, Shen K, Klein M, Tang A, Kane E, Gershow M et al. Two alternating motor programs drive navigation in Drosophila larva. PLoS One. 2011;6(8). e23180. https://doi.org/10.1371/journal.pone.0023180
    Lahiri, Subhaneil ; Shen, Konlin ; Klein, Mason ; Tang, Anji ; Kane, Elizabeth ; Gershow, Marc ; Garrity, Paul ; Samuel, Aravinthan D T. / Two alternating motor programs drive navigation in Drosophila larva. In: PLoS One. 2011 ; Vol. 6, No. 8.
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