Tunable oscillations in the Purkinje neuron

Ze'Ev R. Abrams, Ajithkumar Warrier, Yuan Wang, Dirk Trauner, Xiang Zhang

Research output: Contribution to journalArticle

Abstract

In this paper, we experimentally study the dynamics of slow oscillations in Purkinje neurons in vitro, and derive a strong association with a forced parametric oscillator model. We observed the precise rhythmicity of these oscillations in Purkinje neurons, as well as a dynamic tunability of this oscillation using a photoswitchable compound. We found that this slow oscillation can be induced in every Purkinje neuron measured, having periods ranging between 10 and 25 s. Starting from a Hodgkin-Huxley model, we demonstrate that this oscillation can be externally modulated, and that the neurons will return to their intrinsic firing frequency after the forced oscillation is concluded. These findings signify an additional timing functional role of tunable oscillations within the cerebellum, as well as a dynamic control of a time scale in the brain in the range of seconds.

Original languageEnglish (US)
Article number041905
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume85
Issue number4
DOIs
StatePublished - Apr 9 2012

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neurons
Neuron
Oscillation
oscillations
cerebellum
Cerebellum
Forced oscillation
dynamic control
forced vibration
Dynamic Control
parametric amplifiers
brain
Timing
Time Scales
time measurement
Model
Range of data
Demonstrate

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

Tunable oscillations in the Purkinje neuron. / Abrams, Ze'Ev R.; Warrier, Ajithkumar; Wang, Yuan; Trauner, Dirk; Zhang, Xiang.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 85, No. 4, 041905, 09.04.2012.

Research output: Contribution to journalArticle

Abrams, Ze'Ev R. ; Warrier, Ajithkumar ; Wang, Yuan ; Trauner, Dirk ; Zhang, Xiang. / Tunable oscillations in the Purkinje neuron. In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2012 ; Vol. 85, No. 4.
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