Tumor suppressive functions of ceramide

Evidence and mechanisms

Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil

    Research output: Contribution to journalReview article

    Abstract

    Studies over the past two decades have identified ceramide as a multifunctional central molecule in the sphingolipid biosynthetic pathway. Given its diverse tumor suppressive activities, molecular understanding of ceramide action will produce fundamental insights into processes that limit tumorigenesis and may identify key molecular targets for therapeutic intervention. Ceramide can be activated by a diverse array of stresses such as heat shock, genotoxic damage, oxidative stress and anticancer drugs. Ceramide triggers a variety of tumor suppressive and anti-proliferative cellular programs such as apoptosis, autophagy, senescence, and necroptosis by activating or repressing key effector molecules. Defects in ceramide generation and metabolism in cancer contribute to tumor cell survival and resistance to chemotherapy. The potent and versatile anticancer activity profile of ceramide has motivated drug development efforts to (re-)activate ceramide in established tumors. This review focuses on our current understanding of the tumor suppressive functions of ceramide and highlights the potential downstream targets of ceramide which are involved in its tumor suppressive action.

    Original languageEnglish (US)
    Pages (from-to)689-711
    Number of pages23
    JournalApoptosis
    Volume20
    Issue number5
    DOIs
    StatePublished - Mar 30 2015

    Fingerprint

    Ceramides
    Tumors
    Neoplasms
    Sphingolipids
    Molecules
    Oxidative stress
    Chemotherapy
    Biosynthetic Pathways
    Autophagy
    Metabolism
    Pharmaceutical Preparations
    Shock
    Cell Survival
    Carcinogenesis
    Oxidative Stress
    Hot Temperature
    Cells
    Apoptosis
    Drug Therapy
    Defects

    Keywords

    • Apoptosis
    • Autophagy
    • Ceramide
    • Molecular targets
    • Senescence
    • Tumor suppression

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmaceutical Science
    • Clinical Biochemistry
    • Cell Biology
    • Biochemistry, medical
    • Cancer Research

    Cite this

    Galadari, S., Rahman, A., Pallichankandy, S., & Thayyullathil, F. (2015). Tumor suppressive functions of ceramide: Evidence and mechanisms. Apoptosis, 20(5), 689-711. https://doi.org/10.1007/s10495-015-1109-1

    Tumor suppressive functions of ceramide : Evidence and mechanisms. / Galadari, Sehamuddin; Rahman, Anees; Pallichankandy, Siraj; Thayyullathil, Faisal.

    In: Apoptosis, Vol. 20, No. 5, 30.03.2015, p. 689-711.

    Research output: Contribution to journalReview article

    Galadari, S, Rahman, A, Pallichankandy, S & Thayyullathil, F 2015, 'Tumor suppressive functions of ceramide: Evidence and mechanisms', Apoptosis, vol. 20, no. 5, pp. 689-711. https://doi.org/10.1007/s10495-015-1109-1
    Galadari S, Rahman A, Pallichankandy S, Thayyullathil F. Tumor suppressive functions of ceramide: Evidence and mechanisms. Apoptosis. 2015 Mar 30;20(5):689-711. https://doi.org/10.1007/s10495-015-1109-1
    Galadari, Sehamuddin ; Rahman, Anees ; Pallichankandy, Siraj ; Thayyullathil, Faisal. / Tumor suppressive functions of ceramide : Evidence and mechanisms. In: Apoptosis. 2015 ; Vol. 20, No. 5. pp. 689-711.
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