Tumor-induced structural and radiometric asymmetry in brain images

Peter Lorenzen, Sarang Joshi, Guido Gerig, Elizabeth Bullitt

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    This paper presents a general framework for analyzing structural and radiometric asymmetry in brain images. In a healthy brain, the left and right hemispheres are largely symmetric across the mid-sagittal plane. Brain tumors may belong to one or both of the following categories: mass-effect, in which the diseased tissue displaces healthy tissue; and infiltrating, in which healthy tissue has become diseased. Mass-effect brain tumors cause structural asymmetry by displacing healthy tissue, and may cause radiometric asymmetry in adjacent normal structures due to edema. Infiltrating tumors have a different radiometric response from healthy tissue. Thus, structural and radiometric asymmetries across the mid-sagittal plane in brain images provide important cues that tumors may be present. We have developed a framework that registers images with their reflections across the mid-sagittal plane. The registration process accounts for tissue displacement through large deformation image warping. Radiometric differences are taken into account through an additive intensity field. We present an efficient multi-scale algorithm for the joint estimation of structural and radiometric asymmetry.

    Original languageEnglish (US)
    Title of host publicationProceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis
    EditorsL. Staib
    Pages163-170
    Number of pages8
    StatePublished - 2001
    EventWorkshop on Mathematical Methods in Biomedical Image Analysis MMBIA 2001 - Kauai, HI, United States
    Duration: Dec 9 2001Dec 10 2001

    Other

    OtherWorkshop on Mathematical Methods in Biomedical Image Analysis MMBIA 2001
    CountryUnited States
    CityKauai, HI
    Period12/9/0112/10/01

    Fingerprint

    Asymmetry
    Tumor
    Brain Tumor
    Image Warping
    Normal Structure
    Hemisphere
    Large Deformation
    Registration
    Adjacent
    Brain
    Framework

    Keywords

    • Brain symmetry analysis
    • Deformable image mapping
    • Medical image analysis
    • Plane of symmetry estimation

    ASJC Scopus subject areas

    • Analysis

    Cite this

    Lorenzen, P., Joshi, S., Gerig, G., & Bullitt, E. (2001). Tumor-induced structural and radiometric asymmetry in brain images. In L. Staib (Ed.), Proceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis (pp. 163-170)

    Tumor-induced structural and radiometric asymmetry in brain images. / Lorenzen, Peter; Joshi, Sarang; Gerig, Guido; Bullitt, Elizabeth.

    Proceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis. ed. / L. Staib. 2001. p. 163-170.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Lorenzen, P, Joshi, S, Gerig, G & Bullitt, E 2001, Tumor-induced structural and radiometric asymmetry in brain images. in L Staib (ed.), Proceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis. pp. 163-170, Workshop on Mathematical Methods in Biomedical Image Analysis MMBIA 2001, Kauai, HI, United States, 12/9/01.
    Lorenzen P, Joshi S, Gerig G, Bullitt E. Tumor-induced structural and radiometric asymmetry in brain images. In Staib L, editor, Proceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis. 2001. p. 163-170
    Lorenzen, Peter ; Joshi, Sarang ; Gerig, Guido ; Bullitt, Elizabeth. / Tumor-induced structural and radiometric asymmetry in brain images. Proceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis. editor / L. Staib. 2001. pp. 163-170
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