Triclosan-containing dentifrice may slow periodontal disease progression

Is unsupervised use of a 0.3% triclosan/2% copolymer dentifrice effective in slowing the progression of periodontal disease in a normal adult population?

Research output: Contribution to journalArticle

Abstract

Design The study was a double-blind randomised controlled trail of a general population (members of which were not at risk for periodontal disease).Intervention Subjects in the test group were given a dentifrice containing 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride (Colgate Total; Colgate Palmolive, Sydney, NSW, Australia), whereas members of the control group were supplied with a placebo dentifrice identical to the test dentifrice but not containing the triclosan/copolymer. At the baseline examination, probing pocket depths (PPD) and relative attachment levels were recorded and participants were assigned to either the test or control group. Re-examinations took place after 6, 12, 24, 36, 48 and 60 months.Outcome measures At the baseline and re-examination time points, PPD and relative attachment levels were recorded. Subgingival plaque samples were collected at each examination and assayed for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia.Results On a population basis over a 5-year period, there was little difference in attachment level in the test and control groups. Subjects who had initial PPD ⩾3.5 mm who received the test toothpaste tended to have fewer interproximal PPD ⩾3.5 mm, however, and PPD reductions in sites were higher for those who had PPD ⩾3.5 mm at the previous examinations (P < 0.001). Increasing age, smoking and presence of P. gingivalis had significant effect on PPD reduction.Conclusions In a normal adult population, unsupervised use of a triclosan/copolymer dentifrice tended to slow progression of periodontal disease, and for patients with periodontal disease tended to reduce PPD.

Original languageEnglish (US)
Pages (from-to)107
Number of pages1
JournalEvidence-Based Dentistry
Volume5
Issue number4
DOIs
StatePublished - 2004

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Triclosan
Dentifrices
Periodontal Diseases
Disease Progression
Porphyromonas gingivalis
Control Groups
Population
Prevotella intermedia
Aggregatibacter actinomycetemcomitans
Toothpastes
Sodium Fluoride
Smoking
Placebos
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

@article{26fa550ff67a4a68b3bb8cd640af9edd,
title = "Triclosan-containing dentifrice may slow periodontal disease progression: Is unsupervised use of a 0.3{\%} triclosan/2{\%} copolymer dentifrice effective in slowing the progression of periodontal disease in a normal adult population?",
abstract = "Design The study was a double-blind randomised controlled trail of a general population (members of which were not at risk for periodontal disease).Intervention Subjects in the test group were given a dentifrice containing 0.3{\%} triclosan, 2{\%} copolymer and 0.243{\%} sodium fluoride (Colgate Total; Colgate Palmolive, Sydney, NSW, Australia), whereas members of the control group were supplied with a placebo dentifrice identical to the test dentifrice but not containing the triclosan/copolymer. At the baseline examination, probing pocket depths (PPD) and relative attachment levels were recorded and participants were assigned to either the test or control group. Re-examinations took place after 6, 12, 24, 36, 48 and 60 months.Outcome measures At the baseline and re-examination time points, PPD and relative attachment levels were recorded. Subgingival plaque samples were collected at each examination and assayed for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia.Results On a population basis over a 5-year period, there was little difference in attachment level in the test and control groups. Subjects who had initial PPD ⩾3.5 mm who received the test toothpaste tended to have fewer interproximal PPD ⩾3.5 mm, however, and PPD reductions in sites were higher for those who had PPD ⩾3.5 mm at the previous examinations (P < 0.001). Increasing age, smoking and presence of P. gingivalis had significant effect on PPD reduction.Conclusions In a normal adult population, unsupervised use of a triclosan/copolymer dentifrice tended to slow progression of periodontal disease, and for patients with periodontal disease tended to reduce PPD.",
author = "Richard Niederman",
year = "2004",
doi = "10.1038/sj.ebd.6400278",
language = "English (US)",
volume = "5",
pages = "107",
journal = "Evidence-Based Dentistry",
issn = "1462-0049",
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T1 - Triclosan-containing dentifrice may slow periodontal disease progression

T2 - Is unsupervised use of a 0.3% triclosan/2% copolymer dentifrice effective in slowing the progression of periodontal disease in a normal adult population?

AU - Niederman, Richard

PY - 2004

Y1 - 2004

N2 - Design The study was a double-blind randomised controlled trail of a general population (members of which were not at risk for periodontal disease).Intervention Subjects in the test group were given a dentifrice containing 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride (Colgate Total; Colgate Palmolive, Sydney, NSW, Australia), whereas members of the control group were supplied with a placebo dentifrice identical to the test dentifrice but not containing the triclosan/copolymer. At the baseline examination, probing pocket depths (PPD) and relative attachment levels were recorded and participants were assigned to either the test or control group. Re-examinations took place after 6, 12, 24, 36, 48 and 60 months.Outcome measures At the baseline and re-examination time points, PPD and relative attachment levels were recorded. Subgingival plaque samples were collected at each examination and assayed for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia.Results On a population basis over a 5-year period, there was little difference in attachment level in the test and control groups. Subjects who had initial PPD ⩾3.5 mm who received the test toothpaste tended to have fewer interproximal PPD ⩾3.5 mm, however, and PPD reductions in sites were higher for those who had PPD ⩾3.5 mm at the previous examinations (P < 0.001). Increasing age, smoking and presence of P. gingivalis had significant effect on PPD reduction.Conclusions In a normal adult population, unsupervised use of a triclosan/copolymer dentifrice tended to slow progression of periodontal disease, and for patients with periodontal disease tended to reduce PPD.

AB - Design The study was a double-blind randomised controlled trail of a general population (members of which were not at risk for periodontal disease).Intervention Subjects in the test group were given a dentifrice containing 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride (Colgate Total; Colgate Palmolive, Sydney, NSW, Australia), whereas members of the control group were supplied with a placebo dentifrice identical to the test dentifrice but not containing the triclosan/copolymer. At the baseline examination, probing pocket depths (PPD) and relative attachment levels were recorded and participants were assigned to either the test or control group. Re-examinations took place after 6, 12, 24, 36, 48 and 60 months.Outcome measures At the baseline and re-examination time points, PPD and relative attachment levels were recorded. Subgingival plaque samples were collected at each examination and assayed for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia.Results On a population basis over a 5-year period, there was little difference in attachment level in the test and control groups. Subjects who had initial PPD ⩾3.5 mm who received the test toothpaste tended to have fewer interproximal PPD ⩾3.5 mm, however, and PPD reductions in sites were higher for those who had PPD ⩾3.5 mm at the previous examinations (P < 0.001). Increasing age, smoking and presence of P. gingivalis had significant effect on PPD reduction.Conclusions In a normal adult population, unsupervised use of a triclosan/copolymer dentifrice tended to slow progression of periodontal disease, and for patients with periodontal disease tended to reduce PPD.

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