Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

Theodore B. VanItallie, C. Nonas, A. Di Rocco, Karyn Boyar, K. Hyams, S. B. Heymsfield

Research output: Contribution to journalArticle

Abstract

Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.

Original languageEnglish (US)
Pages (from-to)728-730
Number of pages3
JournalNeurology
Volume64
Issue number4
StatePublished - Feb 22 2005

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Feasibility Studies
Parkinson Disease
Diet
Volunteers
Unsaturated Fats
Placebo Effect
Ketones
Therapeutics
Cholesterol

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

VanItallie, T. B., Nonas, C., Di Rocco, A., Boyar, K., Hyams, K., & Heymsfield, S. B. (2005). Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study. Neurology, 64(4), 728-730.

Treatment of Parkinson disease with diet-induced hyperketonemia : A feasibility study. / VanItallie, Theodore B.; Nonas, C.; Di Rocco, A.; Boyar, Karyn; Hyams, K.; Heymsfield, S. B.

In: Neurology, Vol. 64, No. 4, 22.02.2005, p. 728-730.

Research output: Contribution to journalArticle

VanItallie, TB, Nonas, C, Di Rocco, A, Boyar, K, Hyams, K & Heymsfield, SB 2005, 'Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study', Neurology, vol. 64, no. 4, pp. 728-730.
VanItallie TB, Nonas C, Di Rocco A, Boyar K, Hyams K, Heymsfield SB. Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study. Neurology. 2005 Feb 22;64(4):728-730.
VanItallie, Theodore B. ; Nonas, C. ; Di Rocco, A. ; Boyar, Karyn ; Hyams, K. ; Heymsfield, S. B. / Treatment of Parkinson disease with diet-induced hyperketonemia : A feasibility study. In: Neurology. 2005 ; Vol. 64, No. 4. pp. 728-730.
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