Abstract
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
Original language | English (US) |
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Pages (from-to) | 10-26 |
Number of pages | 17 |
Journal | Neuron |
Volume | 61 |
Issue number | 1 |
DOIs | |
State | Published - Jan 15 2009 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Translational Control of Long-Lasting Synaptic Plasticity and Memory. / Costa-Mattioli, Mauro; Sossin, Wayne S.; Klann, Eric; Sonenberg, Nahum.
In: Neuron, Vol. 61, No. 1, 15.01.2009, p. 10-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Translational Control of Long-Lasting Synaptic Plasticity and Memory
AU - Costa-Mattioli, Mauro
AU - Sossin, Wayne S.
AU - Klann, Eric
AU - Sonenberg, Nahum
PY - 2009/1/15
Y1 - 2009/1/15
N2 - Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
AB - Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=58149469090&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2008.10.055
DO - 10.1016/j.neuron.2008.10.055
M3 - Article
C2 - 19146809
AN - SCOPUS:58149469090
VL - 61
SP - 10
EP - 26
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -