Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

Mimi A. Trinh, Eric Klann

Research output: Contribution to journalArticle

Abstract

Although the requirement for new protein synthesis in synaptic plasticity and memory has been well established, recent genetic, molecular, electrophysiological, and pharmacological studies have broadened our understanding of the translational control mechanisms that are involved in these processes. One of the critical translational control points mediating general and gene-specific translation depends on the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) by four regulatory kinases. Here, we review the literature highlighting the important role for proper translational control via regulation of eIF2α phosphorylation by its kinases in long-lasting synaptic plasticity and long-term memory.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalNeurobiology of Learning and Memory
Volume105
DOIs
StatePublished - Oct 1 2013

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Keywords

  • GCN2
  • HRI
  • Knockout eIF2
  • Long-term memory
  • PERK
  • PKR
  • Synaptic plasticity
  • Translation initiation

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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