Translational and clinical applications of salivary diagnostics.

W. V. Giannobile, J. T. McDevitt, R. S. Niedbala, D. Malamud

Research output: Contribution to journalArticle

Abstract

There have been significant advances in techniques for the detection of biomarker signals in the oral cavity (e.g., ELISAs for proteins, PCR for RNA and DNA) as well as the engineering and development of microfluidic approaches to make oral-based point-of-care (POC) methods for the diagnosis for both local and systemic conditions a reality. In this section, we focus on three such approaches, namely, periodontal disease management, early markers for systemic diseases, and salivary markers useful for pharmacogenomic studies. Novel approaches using non-invasive, salivary samples and user-friendly devices offer results that are as sensitive and specific as laboratory-based analyses using blood or urine.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalAdvances in dental research
Volume23
Issue number4
StatePublished - Oct 2011

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Point-of-Care Systems
Microfluidics
Periodontal Diseases
Disease Management
Mouth
Biomarkers
Enzyme-Linked Immunosorbent Assay
Urine
RNA
Equipment and Supplies
Polymerase Chain Reaction
DNA
Proteins
Pharmacogenomic Testing

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Translational and clinical applications of salivary diagnostics. / Giannobile, W. V.; McDevitt, J. T.; Niedbala, R. S.; Malamud, D.

In: Advances in dental research, Vol. 23, No. 4, 10.2011, p. 375-380.

Research output: Contribution to journalArticle

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