Transition-state stabilization and molecular recognition: Acceleration of phosphoryl-transfer reactions by an artificial receptor

Paolo Tecilla, Suk K. Chang, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with 31P NMR methods show that the receptor causes up to a 10-fold acceleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.

Original languageEnglish (US)
Pages (from-to)9586-9590
Number of pages5
JournalJournal of the American Chemical Society
Volume112
Issue number26
StatePublished - Dec 19 1990

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Artificial Receptors
Molecular recognition
Chlorides
Stabilization
Nuclear magnetic resonance
Derivatives
Kinetics

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Transition-state stabilization and molecular recognition : Acceleration of phosphoryl-transfer reactions by an artificial receptor. / Tecilla, Paolo; Chang, Suk K.; Hamilton, Andrew.

In: Journal of the American Chemical Society, Vol. 112, No. 26, 19.12.1990, p. 9586-9590.

Research output: Contribution to journalArticle

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