Transcription factors in long-term memory and synaptic plasticity

Research output: Contribution to journalArticle

Abstract

Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory formation. Thus, in the last several years, one main interest of molecular neuroscience has been the identification of families of transcription factors that are involved in both of these processes. Transcription is a highly regulated process that involves the combined interaction and function of chromatin and many other proteins, some of which are essential for the basal process of transcription, while others control the selective activation or repression of specific genes. These regulated interactions ultimately allow a sophisticated response to multiple environmental conditions, as well as control of spatial and temporal differences in gene expression. Evidence based on correlative changes in expression, genetic mutations, and targeted molecular inhibition of gene expression have shed light on the function of transcription in both synaptic plasticity and memory formation. This review provides a brief overview of experimental work showing that several families of transcription factors, including CREB, C/EBP, Egr, AP-1, and Rel, have essential functions in both processes. The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.

Original languageEnglish (US)
Pages (from-to)121-145
Number of pages25
JournalPhysiological Reviews
Volume89
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Neuronal Plasticity
Long-Term Memory
Transcription Factors
Gene Expression
Transcription Factor AP-1
Neurosciences
Chromatin
Mutation
Genes
Proteins
Inhibition (Psychology)

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Transcription factors in long-term memory and synaptic plasticity. / Alberini, Cristina.

In: Physiological Reviews, Vol. 89, No. 1, 01.2009, p. 121-145.

Research output: Contribution to journalArticle

@article{07422cdc6aff485f857a193d6f926959,
title = "Transcription factors in long-term memory and synaptic plasticity",
abstract = "Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory formation. Thus, in the last several years, one main interest of molecular neuroscience has been the identification of families of transcription factors that are involved in both of these processes. Transcription is a highly regulated process that involves the combined interaction and function of chromatin and many other proteins, some of which are essential for the basal process of transcription, while others control the selective activation or repression of specific genes. These regulated interactions ultimately allow a sophisticated response to multiple environmental conditions, as well as control of spatial and temporal differences in gene expression. Evidence based on correlative changes in expression, genetic mutations, and targeted molecular inhibition of gene expression have shed light on the function of transcription in both synaptic plasticity and memory formation. This review provides a brief overview of experimental work showing that several families of transcription factors, including CREB, C/EBP, Egr, AP-1, and Rel, have essential functions in both processes. The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.",
author = "Cristina Alberini",
year = "2009",
month = "1",
doi = "10.1152/physrev.00017.2008",
language = "English (US)",
volume = "89",
pages = "121--145",
journal = "Physiological Reviews",
issn = "0031-9333",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Transcription factors in long-term memory and synaptic plasticity

AU - Alberini, Cristina

PY - 2009/1

Y1 - 2009/1

N2 - Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory formation. Thus, in the last several years, one main interest of molecular neuroscience has been the identification of families of transcription factors that are involved in both of these processes. Transcription is a highly regulated process that involves the combined interaction and function of chromatin and many other proteins, some of which are essential for the basal process of transcription, while others control the selective activation or repression of specific genes. These regulated interactions ultimately allow a sophisticated response to multiple environmental conditions, as well as control of spatial and temporal differences in gene expression. Evidence based on correlative changes in expression, genetic mutations, and targeted molecular inhibition of gene expression have shed light on the function of transcription in both synaptic plasticity and memory formation. This review provides a brief overview of experimental work showing that several families of transcription factors, including CREB, C/EBP, Egr, AP-1, and Rel, have essential functions in both processes. The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.

AB - Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory formation. Thus, in the last several years, one main interest of molecular neuroscience has been the identification of families of transcription factors that are involved in both of these processes. Transcription is a highly regulated process that involves the combined interaction and function of chromatin and many other proteins, some of which are essential for the basal process of transcription, while others control the selective activation or repression of specific genes. These regulated interactions ultimately allow a sophisticated response to multiple environmental conditions, as well as control of spatial and temporal differences in gene expression. Evidence based on correlative changes in expression, genetic mutations, and targeted molecular inhibition of gene expression have shed light on the function of transcription in both synaptic plasticity and memory formation. This review provides a brief overview of experimental work showing that several families of transcription factors, including CREB, C/EBP, Egr, AP-1, and Rel, have essential functions in both processes. The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.

UR - http://www.scopus.com/inward/record.url?scp=58249118862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58249118862&partnerID=8YFLogxK

U2 - 10.1152/physrev.00017.2008

DO - 10.1152/physrev.00017.2008

M3 - Article

VL - 89

SP - 121

EP - 145

JO - Physiological Reviews

JF - Physiological Reviews

SN - 0031-9333

IS - 1

ER -