Toxicity of graphene in normal human lung cells (BEAS-2B)

N. V.Srikanth Vallabani, Sandeep Mittal, Ritesh K. Shukla, Alok K. Pandey, Sanjay R. Dhakate, Renu Pasricha, Alok Dhawan

Research output: Contribution to journalArticle

Abstract

Graphite nanomaterials such as thermally exfoliated graphite oxide (GO) are versatile in many applications. However, little is known about its effects on biological systems. In this study we characrerized the GO using dynamic light scattering (DLS) along with the toxicological aspects related to cytotoxicity and apoptosis in normal human lung cells (BEAS-2B). A significant concentration and time dependent decrease in cell viability was observed at different concentrations (10-100 μg/ml) by the MTT assay after 24 and 48 h of exposure and significant increase of early and late apoptotic cells was observed as compared to control cells. Our study demonstrates that GO induces cytotoxicity and apoptosis in human lung cells.

Original languageEnglish (US)
Pages (from-to)106-107
Number of pages2
JournalJournal of Biomedical Nanotechnology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2011

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Keywords

  • Graphene
  • Human lung cells
  • Thermally exfoliated graphite oxide

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Vallabani, N. V. S., Mittal, S., Shukla, R. K., Pandey, A. K., Dhakate, S. R., Pasricha, R., & Dhawan, A. (2011). Toxicity of graphene in normal human lung cells (BEAS-2B). Journal of Biomedical Nanotechnology, 7(1), 106-107. https://doi.org/10.1166/jbn.2011.1224