Towards a shape model of white matter fiber bundles using diffusion tensor MRI

Isabelle Corouge, Sylvain Gouttard, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    White matter fiber bundles of the human brain form a spatial pattern defined by the anatomical and functional architecture. Human brain atlases provide names for individual tracts and document that these patterns are comparable across subjects. Tractography applied to the tensor field in diffusion tensor imaging (DTI) results in sets of streamlines which can be associated with major fiber tracts. Comparison of fiber tract properties across subjects requires comparison at corresponding anatomical locations. As an alternative to linear and nonlinear registration of DTI images and voxel-based analysis, we propose a novel methodology that models the shape of white matter tracts. A clustering uses similarity of adjacent curves and an iterative processing scheme to group sets of curves to bundles and to reject outliers. Unlike previous work which models fiber tracts as sets of curves centered around a spine, we extend the notion of bundling towards a more general representation of manifolds. We describe tracts, represented as sets of curves of similar shape, by a shape prototype swept along a space trajectory. This approach can naturally describe white matter structures observed either as bundles dispersing towards the cortex or tracts defined as dense patterns of parallel fibers forming manifolds. Curves are parameterized by arc-length and represented by intrinsic local shape properties (curvature and torsion). Feasibility is demonstrated by modeling the left and right cortico-spinal tracts and a part of the transversal callosal tract.

    Original languageEnglish (US)
    Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
    Pages344-347
    Number of pages4
    Volume1
    StatePublished - 2004
    Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
    Duration: Apr 15 2004Apr 18 2004

    Other

    Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
    CountryUnited States
    CityArlington, VA
    Period4/15/044/18/04

    Fingerprint

    Magnetic resonance imaging
    Tensors
    Fibers
    Diffusion tensor imaging
    Brain
    Torsional stress
    Trajectories
    Processing

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Corouge, I., Gouttard, S., & Gerig, G. (2004). Towards a shape model of white matter fiber bundles using diffusion tensor MRI. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (Vol. 1, pp. 344-347)

    Towards a shape model of white matter fiber bundles using diffusion tensor MRI. / Corouge, Isabelle; Gouttard, Sylvain; Gerig, Guido.

    2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. Vol. 1 2004. p. 344-347.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Corouge, I, Gouttard, S & Gerig, G 2004, Towards a shape model of white matter fiber bundles using diffusion tensor MRI. in 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. vol. 1, pp. 344-347, 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano, Arlington, VA, United States, 4/15/04.
    Corouge I, Gouttard S, Gerig G. Towards a shape model of white matter fiber bundles using diffusion tensor MRI. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. Vol. 1. 2004. p. 344-347
    Corouge, Isabelle ; Gouttard, Sylvain ; Gerig, Guido. / Towards a shape model of white matter fiber bundles using diffusion tensor MRI. 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. Vol. 1 2004. pp. 344-347
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