Toward theranostic nanoparticles

CB[7] -functionalized iron oxide for drug delivery and MRI

Farah Benyettou, Irena Milosevic, Yoann Lalatonne, Fabienne Warmont, Rana Assah, John Carl Olsen, Mustapha Jouaid, Laurence Motte, Carlos Platas-Iglesias, Ali Trabolsi

    Research output: Contribution to journalArticle

    Abstract

    Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.

    Original languageEnglish (US)
    Pages (from-to)5076-5082
    Number of pages7
    JournalJournal of Materials Chemistry B
    Volume1
    Issue number38
    DOIs
    StatePublished - Oct 14 2013

    Fingerprint

    Drug delivery
    Iron oxides
    Nanoparticles
    Magnetic resonance imaging
    Dyes
    Pharmaceutical Preparations
    Microwave heating
    Coloring Agents
    Magnetic resonance
    Biocompatibility
    Density functional theory
    Microscopic examination
    HCT116 Cells
    Scanning
    Imaging techniques
    Oxygen
    Lasers
    Ions
    Microwaves
    Confocal Microscopy

    ASJC Scopus subject areas

    • Chemistry(all)
    • Medicine(all)
    • Biomedical Engineering
    • Materials Science(all)

    Cite this

    Benyettou, F., Milosevic, I., Lalatonne, Y., Warmont, F., Assah, R., Olsen, J. C., ... Trabolsi, A. (2013). Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI. Journal of Materials Chemistry B, 1(38), 5076-5082. https://doi.org/10.1039/c3tb20852d

    Toward theranostic nanoparticles : CB[7] -functionalized iron oxide for drug delivery and MRI. / Benyettou, Farah; Milosevic, Irena; Lalatonne, Yoann; Warmont, Fabienne; Assah, Rana; Olsen, John Carl; Jouaid, Mustapha; Motte, Laurence; Platas-Iglesias, Carlos; Trabolsi, Ali.

    In: Journal of Materials Chemistry B, Vol. 1, No. 38, 14.10.2013, p. 5076-5082.

    Research output: Contribution to journalArticle

    Benyettou, F, Milosevic, I, Lalatonne, Y, Warmont, F, Assah, R, Olsen, JC, Jouaid, M, Motte, L, Platas-Iglesias, C & Trabolsi, A 2013, 'Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI', Journal of Materials Chemistry B, vol. 1, no. 38, pp. 5076-5082. https://doi.org/10.1039/c3tb20852d
    Benyettou F, Milosevic I, Lalatonne Y, Warmont F, Assah R, Olsen JC et al. Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI. Journal of Materials Chemistry B. 2013 Oct 14;1(38):5076-5082. https://doi.org/10.1039/c3tb20852d
    Benyettou, Farah ; Milosevic, Irena ; Lalatonne, Yoann ; Warmont, Fabienne ; Assah, Rana ; Olsen, John Carl ; Jouaid, Mustapha ; Motte, Laurence ; Platas-Iglesias, Carlos ; Trabolsi, Ali. / Toward theranostic nanoparticles : CB[7] -functionalized iron oxide for drug delivery and MRI. In: Journal of Materials Chemistry B. 2013 ; Vol. 1, No. 38. pp. 5076-5082.
    @article{bd895758ca754d98bd0ccf8da2f41a23,
    title = "Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI",
    abstract = "Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.",
    author = "Farah Benyettou and Irena Milosevic and Yoann Lalatonne and Fabienne Warmont and Rana Assah and Olsen, {John Carl} and Mustapha Jouaid and Laurence Motte and Carlos Platas-Iglesias and Ali Trabolsi",
    year = "2013",
    month = "10",
    day = "14",
    doi = "10.1039/c3tb20852d",
    language = "English (US)",
    volume = "1",
    pages = "5076--5082",
    journal = "Journal of Materials Chemistry B",
    issn = "2050-7518",
    publisher = "Royal Society of Chemistry",
    number = "38",

    }

    TY - JOUR

    T1 - Toward theranostic nanoparticles

    T2 - CB[7] -functionalized iron oxide for drug delivery and MRI

    AU - Benyettou, Farah

    AU - Milosevic, Irena

    AU - Lalatonne, Yoann

    AU - Warmont, Fabienne

    AU - Assah, Rana

    AU - Olsen, John Carl

    AU - Jouaid, Mustapha

    AU - Motte, Laurence

    AU - Platas-Iglesias, Carlos

    AU - Trabolsi, Ali

    PY - 2013/10/14

    Y1 - 2013/10/14

    N2 - Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.

    AB - Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.

    UR - http://www.scopus.com/inward/record.url?scp=84883884449&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84883884449&partnerID=8YFLogxK

    U2 - 10.1039/c3tb20852d

    DO - 10.1039/c3tb20852d

    M3 - Article

    VL - 1

    SP - 5076

    EP - 5082

    JO - Journal of Materials Chemistry B

    JF - Journal of Materials Chemistry B

    SN - 2050-7518

    IS - 38

    ER -