Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI

Farah Benyettou, Irena Milosevic, Yoann Lalatonne, Fabienne Warmont, Rana Assah, John Carl Olsen, Mustapha Jouaid, Laurence Motte, Carlos Platas-Iglesias, Ali Trabolsi

Research output: Contribution to journalArticle

Abstract

Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.

Original languageEnglish (US)
Pages (from-to)5076-5082
Number of pages7
JournalJournal of Materials Chemistry B
Volume1
Issue number38
DOIs
StatePublished - Oct 14 2013

Fingerprint

Drug delivery
Iron oxides
Nanoparticles
Magnetic resonance imaging
Dyes
Pharmaceutical Preparations
Microwave heating
Coloring Agents
Magnetic resonance
Biocompatibility
Density functional theory
Microscopic examination
HCT116 Cells
Scanning
Imaging techniques
Oxygen
Lasers
Ions
Microwaves
Confocal Microscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Toward theranostic nanoparticles : CB[7] -functionalized iron oxide for drug delivery and MRI. / Benyettou, Farah; Milosevic, Irena; Lalatonne, Yoann; Warmont, Fabienne; Assah, Rana; Olsen, John Carl; Jouaid, Mustapha; Motte, Laurence; Platas-Iglesias, Carlos; Trabolsi, Ali.

In: Journal of Materials Chemistry B, Vol. 1, No. 38, 14.10.2013, p. 5076-5082.

Research output: Contribution to journalArticle

Benyettou, F, Milosevic, I, Lalatonne, Y, Warmont, F, Assah, R, Olsen, JC, Jouaid, M, Motte, L, Platas-Iglesias, C & Trabolsi, A 2013, 'Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI', Journal of Materials Chemistry B, vol. 1, no. 38, pp. 5076-5082. https://doi.org/10.1039/c3tb20852d
Benyettou F, Milosevic I, Lalatonne Y, Warmont F, Assah R, Olsen JC et al. Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI. Journal of Materials Chemistry B. 2013 Oct 14;1(38):5076-5082. https://doi.org/10.1039/c3tb20852d
Benyettou, Farah ; Milosevic, Irena ; Lalatonne, Yoann ; Warmont, Fabienne ; Assah, Rana ; Olsen, John Carl ; Jouaid, Mustapha ; Motte, Laurence ; Platas-Iglesias, Carlos ; Trabolsi, Ali. / Toward theranostic nanoparticles : CB[7] -functionalized iron oxide for drug delivery and MRI. In: Journal of Materials Chemistry B. 2013 ; Vol. 1, No. 38. pp. 5076-5082.
@article{bd895758ca754d98bd0ccf8da2f41a23,
title = "Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI",
abstract = "Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.",
author = "Farah Benyettou and Irena Milosevic and Yoann Lalatonne and Fabienne Warmont and Rana Assah and Olsen, {John Carl} and Mustapha Jouaid and Laurence Motte and Carlos Platas-Iglesias and Ali Trabolsi",
year = "2013",
month = "10",
day = "14",
doi = "10.1039/c3tb20852d",
language = "English (US)",
volume = "1",
pages = "5076--5082",
journal = "Journal of Materials Chemistry B",
issn = "2050-7518",
publisher = "Royal Society of Chemistry",
number = "38",

}

TY - JOUR

T1 - Toward theranostic nanoparticles

T2 - CB[7] -functionalized iron oxide for drug delivery and MRI

AU - Benyettou, Farah

AU - Milosevic, Irena

AU - Lalatonne, Yoann

AU - Warmont, Fabienne

AU - Assah, Rana

AU - Olsen, John Carl

AU - Jouaid, Mustapha

AU - Motte, Laurence

AU - Platas-Iglesias, Carlos

AU - Trabolsi, Ali

PY - 2013/10/14

Y1 - 2013/10/14

N2 - Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.

AB - Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.

UR - http://www.scopus.com/inward/record.url?scp=84883884449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883884449&partnerID=8YFLogxK

U2 - 10.1039/c3tb20852d

DO - 10.1039/c3tb20852d

M3 - Article

AN - SCOPUS:84883884449

VL - 1

SP - 5076

EP - 5082

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-7518

IS - 38

ER -