Toward convergence of experimental studies and theoretical modeling of the chromatin fiber

Tamar Schlick, Jeff Hayes, Sergei Grigoryev

Research output: Contribution to journalArticle

Abstract

Understanding the structural organization of eukaryotic chromatin and its control of gene expression represents one of the most fundamental and open challenges in modern biology. Recent experimental advances have revealed important characteristics of chromatin in response to changes in external conditions and histone composition, such as the conformational complexity of linker DNA and histone tail domains upon compact folding of the fiber. In addition, modeling studies based on high-resolution nucleosome models have helped explain the conformational features of chromatin structural elements and their interactions in terms of chromatin fiber models. This minireview discusses recent progress and evidence supporting structural heterogeneity in chromatin fibers, reconciling apparently contradictory fiber models.

Original languageEnglish (US)
Pages (from-to)5183-5191
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number8
DOIs
StatePublished - Feb 17 2012

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Chromatin Assembly and Disassembly
Chromatin
Theoretical Models
Fibers
Histones
Nucleosomes
Gene expression
Gene Expression
DNA
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Toward convergence of experimental studies and theoretical modeling of the chromatin fiber. / Schlick, Tamar; Hayes, Jeff; Grigoryev, Sergei.

In: Journal of Biological Chemistry, Vol. 287, No. 8, 17.02.2012, p. 5183-5191.

Research output: Contribution to journalArticle

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