Toward a prefrontal microcircuit model for cognitive deficits in schizophrenia

Research output: Contribution to journalArticle

Abstract

I present here a biophysically-based model of cortical microcircuits capable of both internal representation (memory storage) and dynamical processing (decision and action selection). The model is illustrated through computer simulations that account for neurophysiological and behavioral data from studies using nonhuman primates. This computational theory proposes that an interplay between slow reverberating excitation and competitive synaptic inhibition enables a cortical area, such as the prefrontal cortex, to subserve cognitive functions. It is argued that quantitatively accurate microcircuit models can potentially provide a framework for a systematic approach to pharmacological treatment of schizophrenia and other mental disorders.

Original languageEnglish (US)
JournalPharmacopsychiatry
Volume39
Issue numberSUPPL. 1
DOIs
StatePublished - Feb 2006

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Prefrontal Cortex
Mental Disorders
Computer Simulation
Cognition
Primates
Schizophrenia
Pharmacology
Inhibition (Psychology)

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Toward a prefrontal microcircuit model for cognitive deficits in schizophrenia. / Wang, Xiao-Jing.

In: Pharmacopsychiatry, Vol. 39, No. SUPPL. 1, 02.2006.

Research output: Contribution to journalArticle

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