Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D

Christopher M. Beaudry, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) A convergent, biomimetic total synthesis of the immunosuppressant polyketides SNF4435 C and D is described. The synthetic pathway features a stereo- and regioselective [3,3]-sigmatropic rearrangement as well as a high-yielding Stille coupling/8π-6π electrocyclization cascade.

Original languageEnglish (US)
Pages (from-to)4475-4477
Number of pages3
JournalOrganic Letters
Volume7
Issue number20
DOIs
StatePublished - Sep 29 2005

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Polyketides
Biomimetics
biomimetics
Immunosuppressive Agents
cascades
synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D. / Beaudry, Christopher M.; Trauner, Dirk.

In: Organic Letters, Vol. 7, No. 20, 29.09.2005, p. 4475-4477.

Research output: Contribution to journalArticle

Beaudry, CM & Trauner, D 2005, 'Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D', Organic Letters, vol. 7, no. 20, pp. 4475-4477. https://doi.org/10.1021/ol051790q
Beaudry, Christopher M. ; Trauner, Dirk. / Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D. In: Organic Letters. 2005 ; Vol. 7, No. 20. pp. 4475-4477.
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