Total Synthesis of (±)-Exotine B

Bichu Cheng, Giulio Volpin, Johannes Morstein, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

The heterodimeric indole/coumarin natural product exotine B was synthesized for the first time. The carbon skeleton of the natural product was formed rapidly by a palladium-catalyzed Suzuki cross-coupling reaction and a gallium-catalyzed three-component [4 + 3] cycloaddition reaction. An alternative biosynthesis of exotine B is proposed based on the total synthesis. Improved syntheses of coumarin natural products gleinadiene and coumurrayin are also reported.

Original languageEnglish (US)
Pages (from-to)4358-4361
Number of pages4
JournalOrganic Letters
Volume20
Issue number14
DOIs
StatePublished - Jul 20 2018

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Cheng, B., Volpin, G., Morstein, J., & Trauner, D. (2018). Total Synthesis of (±)-Exotine B. Organic Letters, 20(14), 4358-4361. https://doi.org/10.1021/acs.orglett.8b01817