Total synthesis of (-)-archazolid B

Paul A. Roethle, Ingrid T. Chen, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.

Original languageEnglish (US)
Pages (from-to)8960-8961
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number29
DOIs
StatePublished - Jul 25 2007

Fingerprint

Lactones
Adenosine Triphosphatases
archazolid B

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Roethle, P. A., Chen, I. T., & Trauner, D. (2007). Total synthesis of (-)-archazolid B. Journal of the American Chemical Society, 129(29), 8960-8961. https://doi.org/10.1021/ja0733033

Total synthesis of (-)-archazolid B. / Roethle, Paul A.; Chen, Ingrid T.; Trauner, Dirk.

In: Journal of the American Chemical Society, Vol. 129, No. 29, 25.07.2007, p. 8960-8961.

Research output: Contribution to journalArticle

Roethle, PA, Chen, IT & Trauner, D 2007, 'Total synthesis of (-)-archazolid B', Journal of the American Chemical Society, vol. 129, no. 29, pp. 8960-8961. https://doi.org/10.1021/ja0733033
Roethle, Paul A. ; Chen, Ingrid T. ; Trauner, Dirk. / Total synthesis of (-)-archazolid B. In: Journal of the American Chemical Society. 2007 ; Vol. 129, No. 29. pp. 8960-8961.
@article{f88f852503bc4391a0f987a756be088d,
title = "Total synthesis of (-)-archazolid B",
abstract = "A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.",
author = "Roethle, {Paul A.} and Chen, {Ingrid T.} and Dirk Trauner",
year = "2007",
month = "7",
day = "25",
doi = "10.1021/ja0733033",
language = "English (US)",
volume = "129",
pages = "8960--8961",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "29",

}

TY - JOUR

T1 - Total synthesis of (-)-archazolid B

AU - Roethle, Paul A.

AU - Chen, Ingrid T.

AU - Trauner, Dirk

PY - 2007/7/25

Y1 - 2007/7/25

N2 - A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.

AB - A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.

UR - http://www.scopus.com/inward/record.url?scp=34547457178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547457178&partnerID=8YFLogxK

U2 - 10.1021/ja0733033

DO - 10.1021/ja0733033

M3 - Article

VL - 129

SP - 8960

EP - 8961

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 29

ER -